{"id":"W2558699479","doi":"10.1107/s2053273314099665","title":"Structural Genomics of Chromatin Regulators for Biological Discovery & Epigenetic Therapy","year":2014,"lang":"en","type":"article","venue":"Acta Crystallographica Section A Foundations and Advances","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Epigenetics; Chromatin; Histone; Computational biology; Biology; Regulation of gene expression; Gene; Epigenesis; Genomics; Epigenomics; Gene expression; Genetics; Cell biology; Genome; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008812026,0.0004573591,0.000533147,0.0004490354,0.0003459326,0.0009992322,0.0007155099,0.0007019757,0.005860236],"category_scores_gemma":[0.0005332947,0.0002631282,0.0003989063,0.0005208195,0.001102707,0.001102466,0.000503097,0.001630296,0.001524557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001363531,"about_ca_system_score_gemma":0.00125123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009279161,"about_ca_topic_score_gemma":0.001282404,"domain_scores_codex":[0.9998065,0.00004868505,0.00000652083,0.00004431256,0.00006709547,0.00002690685],"domain_scores_gemma":[0.9998226,0.00005233898,0.00003363299,0.00003559154,0.00002621274,0.00002966355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004110977,0.0001798089,0.001033506,0.000887343,0.00005256646,0.0002844056,0.0001595992,0.007172565,0.4416564,0.3475867,0.0179559,0.1826203],"study_design_scores_gemma":[0.0001497963,0.000447138,0.001588702,0.000165697,0.0000672602,0.0006283458,0.0001258385,0.00949738,0.4155732,0.1037745,0.4679239,0.00005820741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1592389,0.2577546,0.3874948,0.06749813,0.003168029,0.00040943,0.004437441,0.003352643,0.116646],"genre_scores_gemma":[0.7048071,0.1309716,0.124953,0.003301537,0.0009409318,0.0003365044,0.002590321,0.0003311857,0.03176776],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005860236,"threshold_uncertainty_score":0.01960444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767242190413681,"score_gpt":0.2751964134620693,"score_spread":0.2575239915579325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}