{"id":"W2558807950","doi":"10.4049/jimmunol.1601179","title":"Uric Acid Crystals Induce Placental Inflammation and Alter Trophoblast Function via an IL-1–Dependent Pathway: Implications for Fetal Growth Restriction","year":2016,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Armand Frappier Museum; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Institut National de la Recherche Scientifique; HEC Montréal","funders":"National Center for Advancing Translational Sciences; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Medical Research Council; Canadian Institutes of Health Research","keywords":"Proinflammatory cytokine; Inflammation; Inflammasome; Placenta; Endocrinology; Fetus; Internal medicine; Biology; Trophoblast; Fetal membrane; Cytotrophoblast; Immunology; Medicine; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003277159,0.0001115689,0.0001211108,0.00008489619,0.0001616188,0.00001407805,0.0001497743,0.0001337149,0.000006319652],"category_scores_gemma":[0.00007541577,0.00006913747,0.0000643794,0.00005168452,0.0000936671,0.00003993754,0.00005006286,0.00009550383,0.000002675732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003017908,"about_ca_system_score_gemma":0.00005891771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006187538,"about_ca_topic_score_gemma":0.00001094312,"domain_scores_codex":[0.9991903,0.000141171,0.0003269658,0.0001132407,0.00006035124,0.0001679908],"domain_scores_gemma":[0.9992059,0.00002904311,0.0003361431,0.0001861843,0.0002137078,0.00002898516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001129328,0.00003443511,0.0002644948,0.000003472204,0.0001064403,2.24281e-7,0.00006972974,0.000005028131,0.9793603,0.0001524508,0.00007380681,0.01880029],"study_design_scores_gemma":[0.002174495,0.002986566,0.03010477,0.00001264284,0.00007310597,0.0003242278,0.0002948009,0.000005766215,0.9593527,0.002178501,0.002354548,0.0001378155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9690692,0.0008718094,0.02865978,0.0009195479,0.0002465731,0.0001820736,0.00001649523,0.000004800222,0.00002973261],"genre_scores_gemma":[0.9978433,0.00171424,0.00006474761,0.00004716581,0.0002245428,0.00001374689,0.00002920934,0.00001440435,0.00004864113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02984028,"threshold_uncertainty_score":0.2819344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007385087516126346,"score_gpt":0.2181245179587899,"score_spread":0.2107394304426635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}