{"id":"W2558915591","doi":"10.1016/j.bbrc.2016.11.147","title":"Sequences in Linker-1 domain of the multidrug resistance associated protein (MRP1 or ABCC1) bind to tubulin and their binding is modulated by phosphorylation","year":2016,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Tubulin; Linker; Phosphorylation; Biology; Peptide; Biochemistry; Blot; Serine; Amino acid; Threonine; Molecular biology; Cell biology; Microtubule; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000107479,0.0003634826,0.0002498092,0.0001649399,0.0003111852,0.0002879872,0.000219679,0.0002449653,0.005225207],"category_scores_gemma":[0.0002244489,0.0002065952,0.0003612787,0.0001887879,0.0001798959,0.000228087,0.00024995,0.0004933376,0.001805606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003766639,"about_ca_system_score_gemma":0.0001910311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006572423,"about_ca_topic_score_gemma":0.001235026,"domain_scores_codex":[0.9998949,0.0000223997,0.000005779536,0.00002828489,0.00001693761,0.0000317736],"domain_scores_gemma":[0.9998389,0.00003231284,0.00006190858,0.000009474207,0.00001458814,0.00004285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004995114,0.00005220123,0.0006792594,0.00009029685,0.00001937159,0.0002434019,0.00003367878,0.0002362496,0.9951695,0.0005592822,0.0002452831,0.002171926],"study_design_scores_gemma":[0.0001186617,0.0003930841,0.02474085,0.00004219037,0.00004482567,0.001161716,0.00007305682,0.002270418,0.9602811,0.0003393354,0.01050619,0.00002850652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921923,0.001980386,0.00220404,0.0001192135,0.00005788101,0.00002442311,0.0003127096,0.00005831195,0.003050806],"genre_scores_gemma":[0.9936,0.0006634003,0.001361778,0.0001127912,0.00001815055,0.00002516792,0.001100049,0.000022796,0.003095981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005225207,"threshold_uncertainty_score":0.01748008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04521952851218298,"score_gpt":0.327813130323076,"score_spread":0.282593601810893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}