{"id":"W2559039573","doi":"10.1182/blood.v106.11.2410.2410","title":"Cell Based Assays Completed with the Mantle Cell Lymphoma Cell Lines Z138 and NCEB-1 Indicate That Combinations of Bortezomid and Flavopiridol Interact To Achieve Synergistic Activity.","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Bortezomib; Mantle cell lymphoma; Propidium iodide; Cancer research; Proteasome inhibitor; CHOP; Cyclin D1; Viability assay; Lymphoma; Combination therapy; Medicine; Cytotoxicity; Pharmacology; Cell cycle; Chemistry; Apoptosis; Immunology; Internal medicine; Programmed cell death; Multiple myeloma; In vitro; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001022862,0.0001473624,0.0001374768,0.0000564071,0.00009719534,0.00003359591,0.0001310225,0.00007084637,0.000007714989],"category_scores_gemma":[0.00001717165,0.0001079496,0.00003181084,0.00008434642,0.00009918741,0.000008559414,0.00008220084,0.00006127821,0.000003476405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005879581,"about_ca_system_score_gemma":0.00004277919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002242594,"about_ca_topic_score_gemma":0.00004042947,"domain_scores_codex":[0.9992951,0.00007039747,0.0001242266,0.0002474732,0.0001172863,0.0001455115],"domain_scores_gemma":[0.9994456,0.00004185406,0.0001328418,0.0002439712,0.00005450243,0.00008122148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001328039,0.001063585,0.001299777,0.00005449777,0.000028885,0.000002312408,0.00008925587,0.0000403364,0.9940652,0.000009369602,0.002096193,0.001117819],"study_design_scores_gemma":[0.003106308,0.0004775495,0.00364508,0.00001808485,0.00005731551,0.000004331316,0.00005799277,0.0004665062,0.9859376,0.000003452098,0.006073669,0.0001520863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954528,0.0003158671,0.001833231,0.0009984648,0.00002427743,0.0002973807,0.00005623595,0.00001002198,0.001011747],"genre_scores_gemma":[0.9983583,0.0000362401,0.0006628847,0.0004978309,0.00005248426,0.00002635737,0.00005732122,0.00001731458,0.0002912698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008127539,"threshold_uncertainty_score":0.4402056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007259351326440037,"score_gpt":0.2073523902523494,"score_spread":0.2000930389259094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}