{"id":"W2559039573","doi":"10.1182/blood.v106.11.2410.2410","title":"Cell Based Assays Completed with the Mantle Cell Lymphoma Cell Lines Z138 and NCEB-1 Indicate That Combinations of Bortezomid and Flavopiridol Interact To Achieve Synergistic Activity.","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Bortezomib; Mantle cell lymphoma; Propidium iodide; Cancer research; Proteasome inhibitor; CHOP; Cyclin D1; Viability assay; Lymphoma; Combination therapy; Medicine; Cytotoxicity; Pharmacology; Cell cycle; Chemistry; Apoptosis; Immunology; Internal medicine; Programmed cell death; Multiple myeloma; In vitro; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006077886,0.001097397,0.001003857,0.0006628421,0.0003615928,0.0004693931,0.0006441526,0.0005398336,0.004279653],"category_scores_gemma":[0.000359943,0.0003358936,0.0006560323,0.001128977,0.0003206533,0.0004206279,0.0005270555,0.0009724546,0.001160921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003317043,"about_ca_system_score_gemma":0.0002906043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001358158,"about_ca_topic_score_gemma":0.00255775,"domain_scores_codex":[0.9985045,0.0004226756,0.0001679197,0.000195487,0.0005877102,0.0001217446],"domain_scores_gemma":[0.9994962,0.0001904047,0.00006702432,0.00008164061,0.0001156056,0.00004901594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003101375,0.0003487907,0.0006942087,0.0001854384,0.00004583974,0.00007003624,0.00009058446,0.0001967256,0.9936754,0.0001357872,0.0001918172,0.004055223],"study_design_scores_gemma":[0.00004754241,0.001449394,0.004266074,0.00001288693,0.00004695511,0.0002524577,0.00006102425,0.001077506,0.9907369,0.00004556769,0.001993814,0.00000976468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9397282,0.007562505,0.03231718,0.0002678456,0.0002169671,0.0005625677,0.003854355,0.0006589199,0.01483146],"genre_scores_gemma":[0.9397902,0.002787538,0.03973019,0.0001065568,0.00005299772,0.0006167177,0.007360981,0.00007804683,0.009476818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004279653,"threshold_uncertainty_score":0.01431686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007259351326440037,"score_gpt":0.2073523902523494,"score_spread":0.2000930389259094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}