{"id":"W2559041477","doi":"10.1016/j.psyneuen.2016.11.028","title":"Altered cerebral insulin response in transgenic mice expressing the epsilon-4 allele of the human apolipoprotein E gene","year":2016,"lang":"en","type":"article","venue":"Psychoneuroendocrinology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute on Aging","keywords":"Insulin; Apolipoprotein E; Internal medicine; Endocrinology; Insulin receptor; Neuropathology; Genetically modified mouse; Protein kinase B; Biology; Transgene; Medicine; Signal transduction; Insulin resistance; Cell biology; Gene; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001869377,0.00117939,0.0004622093,0.001003534,0.000288993,0.0005838338,0.000484382,0.0008124529,0.003983304],"category_scores_gemma":[0.0003039701,0.0004593659,0.0004043236,0.0003771373,0.0009265075,0.0003848868,0.0003164278,0.001891275,0.0005580399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005594056,"about_ca_system_score_gemma":0.0004347814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001553859,"about_ca_topic_score_gemma":0.001446779,"domain_scores_codex":[0.9997922,0.00002585325,0.00002259348,0.00006215864,0.00004602498,0.00005117885],"domain_scores_gemma":[0.99958,0.00007352201,0.0001477073,0.00003980295,0.00003162986,0.0001273898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001626433,0.0001634976,0.0002750368,0.00001953725,0.00002372095,0.0004938819,0.00003948094,0.00004892656,0.9963141,0.0001153651,0.00007026349,0.0008097059],"study_design_scores_gemma":[0.0006876527,0.001126789,0.01904717,0.00002433422,0.0003167312,0.002517425,0.0002516923,0.00182421,0.9718601,0.0005831838,0.001697334,0.00006348982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972304,0.0001825199,0.001097523,0.0001808736,0.00009816965,0.00001102508,0.0003906064,0.0001733494,0.0006355593],"genre_scores_gemma":[0.9904625,0.0006701256,0.001547178,0.000183902,0.00003339148,0.00006032431,0.0006824593,0.0002365988,0.006123412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003983304,"threshold_uncertainty_score":0.01332551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04168822123847303,"score_gpt":0.3300347549539033,"score_spread":0.2883465337154302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}