{"id":"W2559063049","doi":"10.1080/10428194.2016.1207765","title":"A common ancestral DNMT3A-mutated preleukemic clone giving rise to AML and MDS in an adolescent girl","year":2016,"lang":"en","type":"letter","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba","funders":"","keywords":"Gene; clone (Java method); Myeloid leukemia; Mutation; Myeloid; Genetics; Biology; Methyltransferase; Cancer research; Medicine; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003185564,0.001120955,0.001032955,0.001465836,0.002189731,0.001047877,0.001005949,0.006523229,0.002454353],"category_scores_gemma":[0.003083928,0.000933296,0.0007570439,0.0008212199,0.001145372,0.001726901,0.001013507,0.005368618,0.0009673841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002076119,"about_ca_system_score_gemma":0.0007660143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002847159,"about_ca_topic_score_gemma":0.003677186,"domain_scores_codex":[0.999463,0.00008578872,0.00005104532,0.0001852461,0.00008634481,0.0001286029],"domain_scores_gemma":[0.998958,0.0003493079,0.0001649921,0.00006799442,0.00008788356,0.0003718158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00004413781,0.00003276285,0.006964033,0.00002910561,0.000007230624,0.987752,0.0001793091,0.00008118658,0.0006474076,0.0007344836,0.001928811,0.001599525],"study_design_scores_gemma":[0.00001973306,0.00006707293,0.005071469,0.00003785134,0.00001268275,0.9911726,0.0001652736,0.0003556871,0.0002541283,0.0005062628,0.002326811,0.00001039415],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8847449,0.00648961,0.002753045,0.07385755,0.002668662,0.0002591094,0.0006436486,0.0002773644,0.02830613],"genre_scores_gemma":[0.9728584,0.003713929,0.002101244,0.01232608,0.003855342,0.00005279199,0.0001820078,0.00006624327,0.00484392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006523229,"threshold_uncertainty_score":0.01506335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01909827924751811,"score_gpt":0.2877261521024222,"score_spread":0.2686278728549041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}