{"id":"W2559092047","doi":"10.1146/annurev-biochem-060815-014207","title":"Conceptual and Experimental Tools to Understand Spatial Effects and Transport Phenomena in Nonlinear Biochemical Networks Illustrated with Patchy Switching","year":2017,"lang":"en","type":"review","venue":"Annual Review of Biochemistry","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Division of Emerging Frontiers; Canadian Institutes of Health Research; National Institutes of Health; Hartwell Foundation; National Science Foundation","keywords":"Nonlinear system; Biological system; Transport phenomena; Statistical physics; Computer science; Physics; Biophysics; Mechanics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004874123,0.0005411837,0.001842683,0.00007389409,0.00004636384,0.00003843085,0.0003966156,0.0004208909,0.00001665022],"category_scores_gemma":[0.0002472641,0.0004365006,0.0001278989,0.0002194965,0.0003974394,0.00007507571,0.000152011,0.0007665993,0.000001673708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001287067,"about_ca_system_score_gemma":0.0001714042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002805518,"about_ca_topic_score_gemma":0.000002422625,"domain_scores_codex":[0.9977697,0.00005454971,0.0007546046,0.0005637273,0.0003876173,0.0004697847],"domain_scores_gemma":[0.99867,0.0002762273,0.00017426,0.0004555435,0.0000563914,0.0003675387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.00002444601,0.00006105557,0.00001138907,0.2215029,0.0001919972,0.00008739759,0.0002315198,0.00000332896,0.0004171845,0.000003686346,0.0001895063,0.7772756],"study_design_scores_gemma":[0.001615026,0.0005247546,0.00002774563,0.6914186,0.0006091151,0.000155858,0.0005545078,0.0002705097,0.007106527,0.000002240512,0.295674,0.002041143],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005382408,0.9928985,0.0002118537,0.00001425109,0.00005234133,0.0009865252,0.0001149102,0.00003918725,0.0002999788],"genre_scores_gemma":[0.01727493,0.9818096,0.0003512391,0.00002954152,0.0002046383,0.00006493557,0.0001811743,0.00006922466,0.00001473384],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7752345,"threshold_uncertainty_score":0.9998087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0319050625972666,"score_gpt":0.3321839080764832,"score_spread":0.3002788454792166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}