{"id":"W2559101087","doi":"10.1021/acsinfecdis.6b00153","title":"Characterization of the Direct Interaction between Hybrid Sensor Kinases PA1611 and RetS That Controls Biofilm Formation and the Type III Secretion System in <i>Pseudomonas aeruginosa</i>","year":2016,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; University of Manitoba; Manitoba Medical Service Foundation; Research Manitoba","keywords":"Biofilm; Pseudomonas aeruginosa; Secretion; Microbiology; Type three secretion system; Kinase; Biology; Chemistry; Cell biology; Biochemistry; Bacteria; Genetics; Gene; Virulence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001132135,0.0002466236,0.0001759689,0.00007701674,0.0001172405,0.0001702468,0.0002636196,0.0002143001,0.0007122685],"category_scores_gemma":[0.0001758104,0.0001044477,0.000241093,0.00008877047,0.0001733568,0.0001581392,0.0001601616,0.0003100188,0.0002886631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002967771,"about_ca_system_score_gemma":0.0001750268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008326057,"about_ca_topic_score_gemma":0.0006727246,"domain_scores_codex":[0.9999205,0.00001812215,0.000009076769,0.00001431147,0.00002472844,0.00001329622],"domain_scores_gemma":[0.9998872,0.00002664457,0.0000407142,0.00000855077,0.00001157685,0.00002526062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001485552,0.00003534311,0.001114056,0.00002399956,0.00001041475,0.0001293405,0.00002024625,0.0003800143,0.9974068,0.0001178126,0.00002179368,0.0005917071],"study_design_scores_gemma":[0.00003066304,0.0002813801,0.01002927,0.000007000173,0.00002334698,0.000773455,0.00007366605,0.00737157,0.9790863,0.00006414963,0.002246792,0.00001235951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989638,0.000136931,0.0005599885,0.00002844967,0.000004142521,0.000004852575,0.00007808189,0.00000611394,0.0002175415],"genre_scores_gemma":[0.9974284,0.0001418858,0.001426556,0.00001938015,0.000002208483,0.000007883216,0.0004178387,0.000008039405,0.0005477658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008326057,"threshold_uncertainty_score":0.002382815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006783570422874586,"score_gpt":0.2073459293791013,"score_spread":0.2005623589562267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}