{"id":"W2559101087","doi":"10.1021/acsinfecdis.6b00153","title":"Characterization of the Direct Interaction between Hybrid Sensor Kinases PA1611 and RetS That Controls Biofilm Formation and the Type III Secretion System in <i>Pseudomonas aeruginosa</i>","year":2016,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; University of Manitoba; Manitoba Medical Service Foundation; Research Manitoba","keywords":"Biofilm; Pseudomonas aeruginosa; Secretion; Microbiology; Type three secretion system; Kinase; Biology; Chemistry; Cell biology; Biochemistry; Bacteria; Genetics; Gene; Virulence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001343123,0.0001197795,0.0001753924,0.0000354587,0.0001066115,0.00003871492,0.00004457466,0.00006432232,0.000001344321],"category_scores_gemma":[0.0001308634,0.00006448287,0.00004490917,0.00006356878,0.0001363519,0.0000330346,0.00006388681,0.00003799789,6.348388e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002194717,"about_ca_system_score_gemma":0.0000177004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006839885,"about_ca_topic_score_gemma":0.0000290775,"domain_scores_codex":[0.999238,0.0001902908,0.0002020106,0.0001756134,0.00007779823,0.0001162977],"domain_scores_gemma":[0.9994181,0.00008822187,0.0002190009,0.0001749847,0.00006693236,0.00003275101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002851347,0.00001359133,0.07401966,0.00003945128,0.00002704828,4.880224e-7,0.00003100013,6.138469e-7,0.9224154,0.00005653518,0.0000134716,0.003097652],"study_design_scores_gemma":[0.002645632,0.0001650055,0.2154129,0.0002711022,0.0001233197,0.00005163892,0.0001014315,0.00004693149,0.7801634,0.00001870881,0.0008270495,0.0001728937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987647,0.0001674447,0.00005530259,0.000188239,0.0002335458,0.0003739419,0.00010082,0.00001778838,0.00009822409],"genre_scores_gemma":[0.9991536,0.0004928759,0.000001580006,0.00006303469,0.0001491913,0.00001250531,0.0001009001,0.00001036492,0.00001590495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1422519,"threshold_uncertainty_score":0.2629535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006783570422874586,"score_gpt":0.2073459293791013,"score_spread":0.2005623589562267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}