{"id":"W2559119413","doi":"10.1107/s2053273314092845","title":"Structural basis for the evolution of vancomycin resistance D,D-peptidases","year":2014,"lang":"en","type":"article","venue":"Acta Crystallographica Section A Foundations and Advances","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Peptidoglycan; Pentapeptide repeat; Operon; Mutagenesis; Autolysin; Biochemistry; Active site; Cell wall; Biology; Chemistry; Peptide; Enzyme; Gene; Mutation; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001846768,0.0001116074,0.0001930821,0.0002259325,0.0004620309,0.00003319085,0.00004896882,0.00004694032,0.00007307039],"category_scores_gemma":[0.0002616608,0.00007807407,0.0001584552,0.0005523908,0.0002631558,0.0002542312,0.00001259697,0.00008448642,9.510797e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003415383,"about_ca_system_score_gemma":0.00003243718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004209737,"about_ca_topic_score_gemma":0.0008942219,"domain_scores_codex":[0.9992002,0.00004006046,0.0002647735,0.0002143181,0.0001501029,0.0001305465],"domain_scores_gemma":[0.998969,0.0003751151,0.0001759844,0.0001997726,0.0002224715,0.00005769112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002338143,0.0007801419,0.109372,0.00226475,0.001509049,0.000002257652,0.001129746,0.0009299273,0.7011474,0.1132758,0.004711373,0.06253936],"study_design_scores_gemma":[0.003286,0.0006302196,0.1862874,0.0008036257,0.0007357595,0.00005315488,0.003882757,0.009748287,0.0005856056,0.01946112,0.7740296,0.0004965022],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8663736,0.001322276,0.1216804,0.006489987,0.0002134619,0.000802705,0.00008506119,0.000136695,0.002895839],"genre_scores_gemma":[0.9966579,0.0002328591,0.002306842,0.0001323421,0.0001541274,0.0000647708,0.00003751753,0.000009251436,0.0004043848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7693182,"threshold_uncertainty_score":0.3553615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085276378402455,"score_gpt":0.2686564123594303,"score_spread":0.2578036485754057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}