{"id":"W2559197523","doi":"10.1093/neuonc/now212.070","title":"ATIM-05. COMPLEMENTARY CLINICAL AND ANCILLARY DATA FROM 123 PATIENTS WITH RECURRENT HIGH GRADE GLIOMA FROM THREE PHASE 1 TRIALS OF TOCA 511 AND TOCA FC: UPDATE AND JUSTIFICATION FOR A PHASE 2/3 TRIAL","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute","funders":"","keywords":"Immune system; Tumor microenvironment; Glioma; Cancer research; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002920307,0.001165366,0.002145371,0.0007250772,0.0005416336,0.001270572,0.001129505,0.001385601,0.009833737],"category_scores_gemma":[0.002689405,0.0004059252,0.001967659,0.000893957,0.0004697825,0.000977179,0.0004501791,0.0022448,0.00257598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001316909,"about_ca_system_score_gemma":0.001083361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001510291,"about_ca_topic_score_gemma":0.004869252,"domain_scores_codex":[0.9990107,0.0005158803,0.00007056871,0.0001240226,0.0001363643,0.0001424061],"domain_scores_gemma":[0.9983184,0.0005474208,0.0003483622,0.0002089427,0.0001551472,0.0004217556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3086472,0.01221147,0.0275687,0.003255107,0.006931835,0.000659527,0.0003529166,0.003471052,0.03407366,0.001140594,0.09735847,0.5043295],"study_design_scores_gemma":[0.3992567,0.290641,0.1257075,0.0005222623,0.008849439,0.003489722,0.0002178977,0.003142213,0.01513932,0.002393935,0.1504537,0.0001862855],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8260829,0.03090356,0.004593995,0.00721336,0.000804449,0.006408097,0.07602587,0.001303986,0.0466637],"genre_scores_gemma":[0.8904556,0.007161014,0.005343686,0.006500195,0.0005663456,0.004833856,0.07536051,0.0002145634,0.009564255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009833737,"threshold_uncertainty_score":0.03289706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1753577743930697,"score_gpt":0.4485427401079663,"score_spread":0.2731849657148966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}