{"id":"W2559258571","doi":"10.1002/1873-3468.12505","title":"Crystal structure of cGMP‐dependent protein kinase Iβ cyclic nucleotide‐binding‐B domain : Rp‐cGMPS complex reveals an apo‐like, inactive conformation","year":2016,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Basic Energy Sciences; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; U.S. Department of Energy; Office of Science; Howard Hughes Medical Institute","keywords":"Chemistry; Protein subunit; Protein kinase A; Stereochemistry; cGMP-dependent protein kinase; Protein structure; Nucleotide; Kinase; Biochemistry; Cyclin-dependent kinase 2; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001928795,0.0003358377,0.0005332039,0.0001235698,0.0003211293,0.000496266,0.0006037298,0.000433709,0.001134575],"category_scores_gemma":[0.0002614542,0.0002530323,0.0001697158,0.0002220818,0.0004664295,0.0002506774,0.0001885082,0.001571381,0.0002275227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000720816,"about_ca_system_score_gemma":0.0005182385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002902788,"about_ca_topic_score_gemma":0.002034671,"domain_scores_codex":[0.9998931,0.00001196431,0.000004748521,0.00003100633,0.00003782021,0.00002143872],"domain_scores_gemma":[0.999859,0.00002542265,0.00003038476,0.00000656007,0.00001439884,0.00006420582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002035418,0.0005611702,0.007457743,0.0005168185,0.0002514367,0.002381232,0.0007464256,0.00400853,0.9646763,0.00236704,0.006116413,0.008881421],"study_design_scores_gemma":[0.002781472,0.00211687,0.1588655,0.0002951249,0.0004551853,0.008550032,0.002004183,0.09776387,0.6675034,0.002903394,0.05644079,0.0003202589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934002,0.002240909,0.001071139,0.0004894653,0.00008348331,0.00002002881,0.0005238983,0.00007985422,0.002091023],"genre_scores_gemma":[0.9920196,0.00131685,0.001930643,0.0003127611,0.00002435211,0.00002717249,0.002663898,0.00003129629,0.001673329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002902788,"threshold_uncertainty_score":0.005771816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01385776472319849,"score_gpt":0.2509905702781638,"score_spread":0.2371328055549653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}