{"id":"W2559269147","doi":"10.1182/blood.v110.11.2571.2571","title":"Treatment of Relapsed or Refractory Lymphoma with the Oral Isotype-Selective Histone Deacetylase Inhibitor MGCD0103: Interim Results from a Phase II Study.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Jewish General Hospital","funders":"","keywords":"Medicine; Tolerability; Follicular lymphoma; Internal medicine; Dosing; Refractory (planetary science); Lymphoma; Gastroenterology; Diffuse large B-cell lymphoma; Interim analysis; Oncology; Pharmacokinetics; Histone deacetylase inhibitor; Clinical trial; Pharmacology; Adverse effect; Histone deacetylase; Chemistry; Biology; Histone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001927542,0.001091563,0.0018162,0.0003388815,0.0003296655,0.0009362583,0.001010955,0.001171388,0.003548937],"category_scores_gemma":[0.0007025261,0.0003996001,0.001242513,0.0003627993,0.0006853045,0.0007282346,0.0003193622,0.002567129,0.0008837365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009131648,"about_ca_system_score_gemma":0.001553776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001339699,"about_ca_topic_score_gemma":0.003421824,"domain_scores_codex":[0.9996921,0.0001190863,0.00001965497,0.00004594039,0.00003305083,0.00009023103],"domain_scores_gemma":[0.9993696,0.0001154743,0.0001038499,0.00006191594,0.00004625382,0.0003029221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5866151,0.08098616,0.007834777,0.001683015,0.002466397,0.0005481765,0.0004010779,0.002673726,0.05740383,0.0004048151,0.008844122,0.2501388],"study_design_scores_gemma":[0.5849873,0.3914568,0.01223896,0.00009204202,0.0006188902,0.0004082373,0.00006319606,0.001130772,0.004283135,0.0002523611,0.004438791,0.00002945559],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829835,0.00662814,0.001239372,0.0005954251,0.0001858375,0.003491111,0.00200239,0.0002051996,0.002668999],"genre_scores_gemma":[0.9777374,0.004697651,0.003091506,0.001873778,0.0002386685,0.003213922,0.005579917,0.00006085284,0.003506227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003548937,"threshold_uncertainty_score":0.01187241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01987054666562553,"score_gpt":0.3220439053516312,"score_spread":0.3021733586860057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}