{"id":"W2559363502","doi":"10.1002/mrd.22762","title":"Altered expression of BRG1 and histone demethylases, and aberrant H3K4 methylation in less developmentally competent embryos at the time of embryonic genome activation","year":2016,"lang":"en","type":"article","venue":"Molecular Reproduction and Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Ste. Anne's Hospital","funders":"Division of Chemistry; Natural Sciences and Engineering Research Council of Canada; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Biology; Epigenetics; Demethylase; Blastocyst; DNA methylation; Embryo; Histone; Chromatin; Genetics; Cell biology; Embryonic stem cell; Methylation; Embryogenesis; Molecular biology; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001199325,0.0001595106,0.0002094058,0.0003225577,0.0001105586,0.0002994481,0.000131962,0.0002865567,0.001054976],"category_scores_gemma":[0.0001717994,0.0001776491,0.0002321574,0.0001228261,0.0001830043,0.0001759072,0.0001612563,0.0004315811,0.0002671708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002456281,"about_ca_system_score_gemma":0.0001443105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001102505,"about_ca_topic_score_gemma":0.0009393915,"domain_scores_codex":[0.9998882,0.000008049222,0.00001006041,0.00004706877,0.00002120686,0.00002547951],"domain_scores_gemma":[0.9998606,0.00002399372,0.00004177052,0.00001516965,0.00001607796,0.00004236931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007806314,0.000003793626,0.001062929,0.00001482863,0.000003562385,0.00005375326,0.00001880021,0.00001447303,0.9982458,0.00002407172,0.000008969871,0.0004709249],"study_design_scores_gemma":[0.00002495152,0.0003795258,0.3061888,0.00001685441,0.0000498927,0.0008320785,0.0002168375,0.0007496266,0.6880959,0.0001370252,0.00328915,0.00001934265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951361,0.001889412,0.001452714,0.00004832167,0.00002737482,0.00001151215,0.00056122,0.0000299383,0.0008433479],"genre_scores_gemma":[0.9926624,0.0007585582,0.001161566,0.0001184464,0.0000103231,0.00002711751,0.0009749109,0.00002351214,0.004263077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001102505,"threshold_uncertainty_score":0.003529251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01442573940309949,"score_gpt":0.2447146170914732,"score_spread":0.2302888776883737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}