{"id":"W2559407770","doi":"10.1002/art.39801","title":"A Phase IIb Study of ABT‐494, a Selective JAK‐1 Inhibitor, in Patients With Rheumatoid Arthritis and an Inadequate Response to Anti–Tumor Necrosis Factor Therapy","year":2016,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"Sanofi; Pfizer; Eli Lilly and Company","keywords":"Rheumatoid arthritis; Medicine; Placebo; Internal medicine; Rheumatology; TNF inhibitor; Methotrexate; Tumor necrosis factor alpha; Gastroenterology; Clinical endpoint; Arthritis; Randomized controlled trial; Etanercept; Pharmacology; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002748637,0.0003243692,0.0009759367,0.0005745819,0.0001285361,0.00002715345,0.0001045319,0.0001022899,0.0001204063],"category_scores_gemma":[0.0003567006,0.0002408912,0.00005872735,0.0004577751,0.0001809922,0.0003270887,0.00005824552,0.0002281232,0.00001597089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007270753,"about_ca_system_score_gemma":0.0001906661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00112743,"about_ca_topic_score_gemma":0.0017419,"domain_scores_codex":[0.9974273,0.0003870615,0.0007702675,0.0006451367,0.0002925608,0.0004776551],"domain_scores_gemma":[0.9983732,0.0003432679,0.0002454605,0.0004152872,0.0003436358,0.0002791739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02463281,0.009688969,0.7173584,0.00001657823,0.000171081,0.0001396583,0.01077962,8.737154e-7,0.06761137,0.00007788674,0.0001911878,0.1693316],"study_design_scores_gemma":[0.117244,0.07172907,0.7634973,0.003435773,0.000013992,0.0005518948,0.001754275,0.00001479487,0.04028676,0.00007499534,0.0007680106,0.0006290933],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974353,0.0003413868,0.00005157034,0.0003659444,0.0001335243,0.001464013,0.0001258302,0.00006842006,0.00001401429],"genre_scores_gemma":[0.9985529,0.000928007,0.0001302104,0.0001295595,0.000009721837,0.0001749842,0.0000116335,0.00005509861,0.00000790769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1687025,"threshold_uncertainty_score":0.9823256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318001785598118,"score_gpt":0.2812696128087854,"score_spread":0.2680895949528042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}