{"id":"W2559407770","doi":"10.1002/art.39801","title":"A Phase IIb Study of ABT‐494, a Selective JAK‐1 Inhibitor, in Patients With Rheumatoid Arthritis and an Inadequate Response to Anti–Tumor Necrosis Factor Therapy","year":2016,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"Sanofi; Pfizer; Eli Lilly and Company","keywords":"Rheumatoid arthritis; Medicine; Placebo; Internal medicine; Rheumatology; TNF inhibitor; Methotrexate; Tumor necrosis factor alpha; Gastroenterology; Clinical endpoint; Arthritis; Randomized controlled trial; Etanercept; Pharmacology; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002108535,0.0015958,0.002310297,0.0004509247,0.0004177691,0.0006572618,0.0006898745,0.001364683,0.003888909],"category_scores_gemma":[0.001277147,0.0007041664,0.001355927,0.0004022978,0.0007077526,0.0005419305,0.0002670219,0.00155479,0.0008307018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004899365,"about_ca_system_score_gemma":0.0008419609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007248893,"about_ca_topic_score_gemma":0.001325017,"domain_scores_codex":[0.9992774,0.0004458969,0.00004519059,0.00008007226,0.00005591246,0.00009559316],"domain_scores_gemma":[0.9992728,0.0002062535,0.0001690873,0.00005610299,0.00004944947,0.0002464084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9207048,0.01725555,0.005013749,0.0007361743,0.001396904,0.0002071427,0.000109361,0.0007492014,0.0198736,0.00009704734,0.001286776,0.03256964],"study_design_scores_gemma":[0.8457593,0.1423281,0.009086275,0.00002056791,0.0005136331,0.0001271908,0.00001925481,0.0004484023,0.0008372912,0.00004921108,0.0007964498,0.0000143862],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900134,0.003797224,0.0006930226,0.000420538,0.000197095,0.002387577,0.0007554574,0.00009441494,0.001641345],"genre_scores_gemma":[0.9889355,0.00253099,0.001466971,0.0009935726,0.0004791092,0.002461989,0.001418007,0.00002077047,0.001693006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003888909,"threshold_uncertainty_score":0.01300967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318001785598118,"score_gpt":0.2812696128087854,"score_spread":0.2680895949528042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}