{"id":"W2559410842","doi":"10.1128/aac.01805-16","title":"Frequent Cross-Resistance to Dapivirine in HIV-1 Subtype C-Infected Individuals after First-Line Antiretroviral Therapy Failure in South Africa","year":2016,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver","funders":"Bill and Melinda Gates Foundation","keywords":"Efavirenz; Nevirapine; Virology; Reverse-transcriptase inhibitor; Drug resistance; Reverse transcriptase; Viral load; Biology; Antiretroviral therapy; Human immunodeficiency virus (HIV); Medicine; Microbiology; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002453288,0.0003413671,0.000313176,0.0007423448,0.0007392808,0.0004883766,0.0001919233,0.0004674274,0.0020262],"category_scores_gemma":[0.001294093,0.0002390618,0.0001683369,0.0005680472,0.0003694142,0.0002962993,0.0002925818,0.0003080134,0.0001547105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003807182,"about_ca_system_score_gemma":0.0001897724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007600695,"about_ca_topic_score_gemma":0.007222893,"domain_scores_codex":[0.9997395,0.00005428184,0.00002371945,0.00006750422,0.0000419556,0.00007304762],"domain_scores_gemma":[0.9996189,0.00009926288,0.0001479791,0.00002418503,0.00005072671,0.00005891977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000281311,0.00005314255,0.9714547,0.00005768569,0.00003998146,0.002924071,0.00219501,0.00003499335,0.01705427,0.00003754775,0.0001253715,0.005741843],"study_design_scores_gemma":[0.00001900312,0.0003375464,0.9866858,0.00003409517,0.00003521395,0.007632576,0.002320153,0.0002016627,0.002107898,0.00003142396,0.0005819921,0.0000127554],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996884,0.0001016877,0.00002976858,0.00001528101,0.000001338607,0.000006206799,0.00002908584,0.000001593907,0.0001266856],"genre_scores_gemma":[0.9998285,0.00004522837,0.00003621055,0.00001767982,0.000001419681,0.00000236831,0.00002122469,8.155513e-7,0.00004646955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007600695,"threshold_uncertainty_score":0.01511294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01429281930543614,"score_gpt":0.2568174549041713,"score_spread":0.2425246355987352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}