{"id":"W2559481363","doi":"10.1107/s2053273314096946","title":"KCTD proteins as Cullin3 E3 Ligase adapters","year":2014,"lang":"en","type":"article","venue":"Acta Crystallographica Section A Foundations and Advances","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"","keywords":"Ubiquitin ligase; Ubiquitin; Ubiquitin-Protein Ligases; DNA ligase; Chemistry; Moiety; C-terminus; Protein structure; Signal transducing adaptor protein; Stereochemistry; Biochemistry; Biophysics; Cell biology; Biology; Enzyme; Receptor; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001075847,0.0002717444,0.0002596504,0.000263778,0.0003693316,0.0007200598,0.0004220084,0.0002844724,0.002337332],"category_scores_gemma":[0.0001248471,0.0001694652,0.0001743875,0.0005914774,0.0002392234,0.0003464263,0.0002938117,0.0003470054,0.001316956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009475707,"about_ca_system_score_gemma":0.0004561841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002396414,"about_ca_topic_score_gemma":0.001746898,"domain_scores_codex":[0.9998982,0.000008097062,0.000008247224,0.00002341347,0.00004131477,0.00002064406],"domain_scores_gemma":[0.9999514,0.000003605416,0.00001381123,0.000008308355,0.00001105532,0.00001176579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008007755,0.000105242,0.0105696,0.0013723,0.0001048479,0.002093941,0.0002823819,0.006531008,0.8353021,0.02281054,0.01532378,0.1047035],"study_design_scores_gemma":[0.0001116376,0.00009515517,0.0192903,0.0001059852,0.0000742356,0.004286297,0.0002230495,0.01112374,0.590814,0.005840349,0.3679836,0.00005170079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8177146,0.08176357,0.05622011,0.00184215,0.0005898599,0.0001252928,0.00659313,0.002734093,0.03241715],"genre_scores_gemma":[0.9468206,0.01988562,0.01451047,0.000226933,0.0000492168,0.00002622267,0.003938302,0.00007008006,0.01447247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002396414,"threshold_uncertainty_score":0.007819176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008385610763389721,"score_gpt":0.2464855651981463,"score_spread":0.2380999544347566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}