{"id":"W2559499796","doi":"10.1182/blood.v110.11.1507.1507","title":"A High Throughput Screen Identified Cyproheptadine That Decreases D-Type Cyclins, Arrests Cells in the G1 Phase, and Induces Apoptosis in Multiple Myeloma and Leukemia Cells.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Cyproheptadine; Cancer research; Viability assay; Cyclin B; Cyclin; Cyclin D; Cyclin D1; Cyclin B1; Cyclin D3; Apoptosis; Cell cycle checkpoint; Cyclin A; Cell cycle; Cell growth; Biology; Cyclin E; Cyclin-dependent kinase 1; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004804901,0.0002838736,0.0004461187,0.0002297408,0.00008700489,0.00005066755,0.0001628028,0.0001474869,0.00002078173],"category_scores_gemma":[0.0001013085,0.0002141147,0.00004359963,0.0004639594,0.0002200244,0.0002307489,0.0000745067,0.0003201782,0.000005052631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007223155,"about_ca_system_score_gemma":0.0000860075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001849043,"about_ca_topic_score_gemma":0.0018639,"domain_scores_codex":[0.9982903,0.00007458583,0.0003795195,0.0004890308,0.0003196384,0.0004469219],"domain_scores_gemma":[0.9988661,0.000428638,0.0001360189,0.0003763737,0.00004646419,0.0001464212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002926159,0.002144348,0.2039027,0.0002478264,0.0002526851,0.0004374994,0.004576862,0.00001540805,0.7217068,0.00008200815,0.0001723284,0.06353536],"study_design_scores_gemma":[0.01712293,0.0003190179,0.3049858,0.000318189,0.0001709826,0.00007867797,0.001599811,0.00001947039,0.6738926,0.0002872742,0.0009223882,0.000282952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933102,0.005368345,0.00008250782,0.0002081294,0.0001361311,0.0007157819,0.00002825341,0.00004803579,0.0001026673],"genre_scores_gemma":[0.9962132,0.0009668691,0.00199446,0.00046009,0.0002052164,0.00002835293,0.000038463,0.00003878781,0.00005453482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1010831,"threshold_uncertainty_score":0.8731343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02688506457725748,"score_gpt":0.2904661611743126,"score_spread":0.2635810965970551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}