{"id":"W2559499796","doi":"10.1182/blood.v110.11.1507.1507","title":"A High Throughput Screen Identified Cyproheptadine That Decreases D-Type Cyclins, Arrests Cells in the G1 Phase, and Induces Apoptosis in Multiple Myeloma and Leukemia Cells.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Cyproheptadine; Cancer research; Viability assay; Cyclin B; Cyclin; Cyclin D; Cyclin D1; Cyclin B1; Cyclin D3; Apoptosis; Cell cycle checkpoint; Cyclin A; Cell cycle; Cell growth; Biology; Cyclin E; Cyclin-dependent kinase 1; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000201699,0.0006000627,0.0008085115,0.0008245839,0.0002787646,0.0003110408,0.0003662237,0.0004075016,0.002077529],"category_scores_gemma":[0.0002015106,0.0002336372,0.0005371896,0.0008565619,0.0001486722,0.0001748625,0.0002259054,0.000389008,0.0006533857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003532018,"about_ca_system_score_gemma":0.0003539179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001045873,"about_ca_topic_score_gemma":0.003935616,"domain_scores_codex":[0.9998012,0.00002459599,0.00001628063,0.00004707886,0.00008676809,0.000024005],"domain_scores_gemma":[0.9998912,0.00003090115,0.00002051552,0.000009620861,0.00002628533,0.00002150451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002760221,0.0002505267,0.0008751879,0.0002330983,0.00004997034,0.0002029719,0.00001560291,0.0003236521,0.9870983,0.00004602417,0.0004020523,0.01022651],"study_design_scores_gemma":[0.0001710077,0.003483799,0.01515632,0.00002944297,0.0003098524,0.001210602,0.00004094076,0.002068527,0.9686998,0.00005697065,0.008745548,0.00002711237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623652,0.01055667,0.00842262,0.0004183162,0.00006151575,0.0006562456,0.01096931,0.0007215835,0.005828581],"genre_scores_gemma":[0.9513049,0.008762016,0.0136854,0.0003751702,0.00002800567,0.0002879142,0.01657656,0.00008335989,0.008896706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002077529,"threshold_uncertainty_score":0.006950021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02688506457725748,"score_gpt":0.2904661611743126,"score_spread":0.2635810965970551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}