{"id":"W2559505112","doi":"10.1107/s2053273314091876","title":"Structural Basis of Prion Protein Conformation Conversion Inhibition","year":2014,"lang":"en","type":"article","venue":"Acta Crystallographica Section A Foundations and Advances","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Promazine; Chemistry; Small molecule; Gene isoform; Phenothiazine; Prion protein; Protein aggregation; Biochemistry; Plasma protein binding; Stereochemistry; Chlorpromazine; Biophysics; Biology; Pharmacology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000928199,0.0002659532,0.0001740253,0.0001013579,0.000173947,0.000259591,0.0004279258,0.0002543026,0.001366858],"category_scores_gemma":[0.0001771893,0.0001333081,0.0001669542,0.00007021429,0.0003338397,0.000145014,0.0001849434,0.0005126193,0.0002790417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003564763,"about_ca_system_score_gemma":0.0001976515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005511876,"about_ca_topic_score_gemma":0.0003537711,"domain_scores_codex":[0.9999176,0.00001222766,0.000004088439,0.00001795364,0.00002552649,0.00002259082],"domain_scores_gemma":[0.9999127,0.00001983154,0.00002618202,0.000008406319,0.00001403715,0.00001873287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001951445,0.00008026415,0.0005491317,0.00008129963,0.00001227613,0.000345916,0.00002751545,0.002266654,0.9897984,0.003201431,0.0002618043,0.003180127],"study_design_scores_gemma":[0.0001552217,0.0009892349,0.006021262,0.00002798245,0.00003421191,0.001128106,0.00004065656,0.01645704,0.9649478,0.002201739,0.007976039,0.00002075948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759045,0.003141276,0.006504031,0.0005214479,0.00005997271,0.0000762774,0.0002658507,0.0001942402,0.01333229],"genre_scores_gemma":[0.9976885,0.0005423107,0.0006380381,0.00008543998,0.000006942092,0.00001686,0.0001395144,0.00000785161,0.0008745041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001366858,"threshold_uncertainty_score":0.00457257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005837371756779125,"score_gpt":0.2328668823844736,"score_spread":0.2270295106276945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}