{"id":"W2559572693","doi":"10.1182/blood.v116.21.252.252","title":"Self-Complementary AAV Vectors Cause a Substantially Heightened TLR9-Dependent Innate Immune Response In the Liver","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Immune system; Capsid; Biology; Vector (molecular biology); Genetic enhancement; Transduction (biophysics); TLR9; Chemokine; Innate immune system; Immunology; Virology; Molecular biology; Recombinant DNA; Gene; Virus; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001368059,0.0003103169,0.0001790793,0.0001631601,0.00006440099,0.0002197234,0.0000845511,0.0002588987,0.001822238],"category_scores_gemma":[0.0000995494,0.0001332339,0.0002000673,0.00006737062,0.0002012416,0.0001678615,0.0001332706,0.0005595565,0.0004138464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001491553,"about_ca_system_score_gemma":0.00009564511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001830743,"about_ca_topic_score_gemma":0.000214931,"domain_scores_codex":[0.9998118,0.00002152944,0.00001983018,0.00004559503,0.00005365137,0.00004763967],"domain_scores_gemma":[0.9998497,0.00002607604,0.00005348135,0.00001844783,0.00001545604,0.00003675947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003015502,0.00001022521,0.00007821312,0.00000740311,0.000001009762,0.00001459342,0.000003392071,0.000006395155,0.9996469,0.00001369018,0.000008172346,0.0001799706],"study_design_scores_gemma":[0.00001276769,0.0007366899,0.003924474,0.000003847038,0.000007056337,0.0003036612,0.00002583026,0.0003663287,0.993958,0.00003226595,0.0006263907,0.000002690592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963714,0.000372847,0.002234806,0.00004533477,0.00003171845,0.00002258928,0.000171101,0.0001135076,0.0006366594],"genre_scores_gemma":[0.9944807,0.0002079413,0.001971526,0.00005690054,0.00001364892,0.00003836346,0.0003345998,0.00001852102,0.002877741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001822238,"threshold_uncertainty_score":0.006096005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01494602926121875,"score_gpt":0.2766579552862088,"score_spread":0.2617119260249901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}