{"id":"W2559595459","doi":"10.1182/blood.v124.21.4138.4138","title":"RIAM Interacts with the Hematopoietic-Specific Adaptor Protein Gads and Forms a LAT-Independent Node of Signal Integration That Regulates Activation of PLC-γ1","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Pleckstrin homology domain; Signal transducing adaptor protein; Second messenger system; Cell biology; Phosphorylation; Phosphatidylinositol; Diacylglycerol kinase; Biology; Tyrosine phosphorylation; Gq alpha subunit; Inositol; Signal transduction; Biochemistry; G protein; Protein kinase C; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002290332,0.0001173474,0.0001417691,0.00003692464,0.00004803153,0.00001848747,0.00008537983,0.00008752981,0.000009277339],"category_scores_gemma":[0.00002589119,0.00007337402,0.00004265792,0.00005771186,0.00008176748,0.00001179141,0.00004190176,0.0000650423,3.367253e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004891713,"about_ca_system_score_gemma":0.00002149914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008425395,"about_ca_topic_score_gemma":0.00001433616,"domain_scores_codex":[0.9993038,0.00005714356,0.0001763658,0.0001849285,0.0001745988,0.0001031176],"domain_scores_gemma":[0.9993597,0.00001795995,0.0002716645,0.0002146616,0.0001030778,0.00003294933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001848887,0.0001041333,0.0003602116,0.00004390177,0.00003981461,2.606697e-7,0.0001255315,0.00003465141,0.9971427,0.0008496601,0.00001757261,0.001096635],"study_design_scores_gemma":[0.001014715,0.000266409,0.002513975,0.0002199356,0.00002180403,0.000009179036,0.0001924385,0.0002364921,0.9949228,0.0002518147,0.0002545106,0.00009592557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980828,0.0001811703,0.01831833,0.0001624024,0.000008134734,0.0003467293,0.000004890639,0.000006466347,0.0001438496],"genre_scores_gemma":[0.9987597,0.00001186652,0.001025255,0.0000249245,0.00005436783,0.00003178254,0.00002989948,0.0000132693,0.0000489442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01793167,"threshold_uncertainty_score":0.2992105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009069318273871012,"score_gpt":0.2064282753320202,"score_spread":0.1973589570581492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}