{"id":"W2559595459","doi":"10.1182/blood.v124.21.4138.4138","title":"RIAM Interacts with the Hematopoietic-Specific Adaptor Protein Gads and Forms a LAT-Independent Node of Signal Integration That Regulates Activation of PLC-γ1","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Pleckstrin homology domain; Signal transducing adaptor protein; Second messenger system; Cell biology; Phosphorylation; Phosphatidylinositol; Diacylglycerol kinase; Biology; Tyrosine phosphorylation; Gq alpha subunit; Inositol; Signal transduction; Biochemistry; G protein; Protein kinase C; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001115601,0.000340424,0.000179435,0.0003133953,0.0002486152,0.0003480504,0.0002715686,0.000252382,0.0013259],"category_scores_gemma":[0.0001687084,0.0002204707,0.0004071467,0.0001625495,0.0002363032,0.000135333,0.0004872615,0.0004285547,0.001486215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004643409,"about_ca_system_score_gemma":0.0001241317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002000783,"about_ca_topic_score_gemma":0.0003418703,"domain_scores_codex":[0.9998299,0.00002129546,0.000009821631,0.00005707037,0.0000446296,0.00003742578],"domain_scores_gemma":[0.9998991,0.000007505867,0.00003660875,0.00001677686,0.00001053847,0.00002951262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003331279,0.0000081043,0.0006355884,0.00002109796,0.000005905385,0.000137233,0.000007678649,0.00003180436,0.9980376,0.0001760741,0.00007052607,0.0008349415],"study_design_scores_gemma":[0.00004449351,0.0001738358,0.05761379,0.00002383042,0.00003132672,0.003260462,0.00007800859,0.003302892,0.9208471,0.0002421617,0.01436769,0.00001446395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881556,0.001755213,0.005526528,0.0001385402,0.00003638883,0.00002788528,0.0002622321,0.0002275671,0.003869938],"genre_scores_gemma":[0.9917203,0.0003947325,0.003745823,0.00008488345,0.00001602833,0.00002715771,0.0006029626,0.00002937323,0.003378709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0013259,"threshold_uncertainty_score":0.004435599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009069318273871012,"score_gpt":0.2064282753320202,"score_spread":0.1973589570581492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}