{"id":"W2559664119","doi":"10.1074/jbc.m116.744235","title":"Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; University of Calgary; Hamilton Health Sciences; Libin Cardiovascular Institute of Alberta; Thrombosis and Atherosclerosis Research Institute; Université de Montréal; Population Health Research Institute; McMaster University; St. Joseph’s Healthcare Hamilton","funders":"Canadian Institutes of Health Research","keywords":"Endoplasmic reticulum; Unfolded protein response; PCSK9; LDL receptor; Thapsigargin; Cell biology; Biology; Lipid metabolism; XBP1; Endocrinology; Sterol regulatory element-binding protein; Internal medicine; Secretion; Sterol; Cholesterol; Lipoprotein; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003995769,0.0002125304,0.0005531828,0.00003335328,0.0000623905,0.00003044397,0.0001828823,0.0002047636,0.0001210092],"category_scores_gemma":[0.0003669953,0.00008771276,0.0001861463,0.00006130026,0.000176308,0.00005844003,0.0000694528,0.0003239316,0.000005048875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002985476,"about_ca_system_score_gemma":0.00004468604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002152281,"about_ca_topic_score_gemma":7.881433e-7,"domain_scores_codex":[0.9985738,0.0001059553,0.0005370726,0.0002386395,0.0002718987,0.0002726218],"domain_scores_gemma":[0.9988018,0.00009785109,0.0003247445,0.0002669081,0.0001833369,0.0003253512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007776952,0.00009734803,0.00382685,0.00004507227,0.0001002495,0.00002099462,0.00003660345,0.000001382989,0.9887098,0.00002141523,0.00008447638,0.006278091],"study_design_scores_gemma":[0.005086307,0.000310652,0.2281439,0.0004339421,0.0002104446,0.0004754302,0.00004766456,0.00001288843,0.757872,0.000166949,0.007065358,0.0001744805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933684,0.0006382295,0.0004591975,0.004915333,0.0001988633,0.0003031261,0.00002766072,0.00001845632,0.00007070372],"genre_scores_gemma":[0.9971575,0.000114876,0.0001309542,0.0005219361,0.001595183,0.00001519442,0.000001928304,0.00001324178,0.0004491446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2308378,"threshold_uncertainty_score":0.3576823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136219219534631,"score_gpt":0.2224797036812455,"score_spread":0.2111175114858992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}