{"id":"W2559690752","doi":"10.1093/nar/gkw1161","title":"ING1 regulates rRNA levels by altering nucleolar chromatin structure and mTOR localization","year":2016,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Nutrition Obesity Research Center, University of North Carolina","keywords":"Biology; Nucleolus; Chromatin; Transcription (linguistics); Histone; Transcriptional regulation; Epigenetics; Heterochromatin; PI3K/AKT/mTOR pathway; Cell biology; Transcription factor; Molecular biology; Genetics; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009582358,0.0004887469,0.0002576785,0.0002413066,0.0002187623,0.0003913747,0.0002842959,0.0002304751,0.001538869],"category_scores_gemma":[0.00008374875,0.0001563618,0.0002478855,0.0001449996,0.0002222393,0.0001605518,0.0002544275,0.000379046,0.0005916122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00045016,"about_ca_system_score_gemma":0.0001896514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005810058,"about_ca_topic_score_gemma":0.001215655,"domain_scores_codex":[0.9999115,0.000008823997,0.000005699423,0.00002807667,0.00001914776,0.00002667884],"domain_scores_gemma":[0.999934,0.000007193366,0.00002470171,0.000009076407,0.00000750741,0.00001754703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006757917,0.00001307516,0.0003888214,0.00003906072,0.000004194616,0.00003720275,0.00001108348,0.00007591389,0.9972072,0.0001643997,0.00005399239,0.001937613],"study_design_scores_gemma":[0.000003619624,0.00006663564,0.007280797,0.000006120912,0.00001545776,0.0001356342,0.00002830573,0.0004811395,0.9879709,0.00007875016,0.00392853,0.000004115264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795169,0.007556154,0.005890789,0.0002155608,0.00006950431,0.00002245863,0.0009326931,0.0003690588,0.005427041],"genre_scores_gemma":[0.9896746,0.00242343,0.002633184,0.0000652495,0.00001582792,0.00001904262,0.001068363,0.00006009271,0.004040144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001538869,"threshold_uncertainty_score":0.005148053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02628218603927689,"score_gpt":0.3143806295444132,"score_spread":0.2880984435051363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}