{"id":"W2559722650","doi":"10.1071/rdv29n1ab70","title":"70 XBP1 DYSREGULATION BY CRISPR/Cas9-MEDIATED GENE EDITING DURING PORCINE EMBRYO EARLY DEVELOPMENT","year":2016,"lang":"en","type":"article","venue":"Reproduction Fertility and Development","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"XBP1; Biology; Unfolded protein response; Cell biology; Endoplasmic reticulum; Cas9; Embryo; CRISPR; Molecular biology; Genetics; Gene; RNA; RNA splicing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002572428,0.0002519291,0.0002744235,0.0001489149,0.0001859428,0.000333269,0.000270683,0.0004390746,0.001529309],"category_scores_gemma":[0.0001548601,0.0002337366,0.0003751447,0.00009170669,0.0002309515,0.0001419313,0.0002821021,0.000468709,0.0004463785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002095288,"about_ca_system_score_gemma":0.0003065369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001254563,"about_ca_topic_score_gemma":0.00114422,"domain_scores_codex":[0.9997389,0.00003594219,0.00003572908,0.00007233203,0.00006792582,0.00004917994],"domain_scores_gemma":[0.9999167,0.00001848103,0.00002569357,0.00001175587,0.00001056992,0.00001678181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000636307,0.00001092757,0.0001709455,0.00005646552,0.000003615701,0.0001466746,0.00002620217,0.0001065078,0.9981622,0.0001088745,0.00006598291,0.001078031],"study_design_scores_gemma":[0.00002907345,0.0003020306,0.005492904,0.00002440947,0.00003371036,0.0007482994,0.00004363389,0.002164753,0.9805361,0.00005226862,0.01055783,0.00001507488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613079,0.003569572,0.0229328,0.0002104964,0.0002563352,0.0002630445,0.001460898,0.0004853654,0.00951363],"genre_scores_gemma":[0.9714096,0.002054884,0.01541497,0.0001854888,0.00001907086,0.0002840324,0.001442154,0.0001153555,0.009074423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001529309,"threshold_uncertainty_score":0.005116045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007998385453010851,"score_gpt":0.2418763355962136,"score_spread":0.2338779501432028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}