{"id":"W2559722650","doi":"10.1071/rdv29n1ab70","title":"70 XBP1 DYSREGULATION BY CRISPR/Cas9-MEDIATED GENE EDITING DURING PORCINE EMBRYO EARLY DEVELOPMENT","year":2016,"lang":"en","type":"article","venue":"Reproduction Fertility and Development","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"XBP1; Biology; Unfolded protein response; Cell biology; Endoplasmic reticulum; Cas9; Embryo; CRISPR; Molecular biology; Genetics; Gene; RNA; RNA splicing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003829381,0.0002058732,0.0001532,0.00005837947,0.0002204474,0.00002573386,0.00007164884,0.0001197517,0.00002731773],"category_scores_gemma":[0.0001445375,0.0001732861,0.00002580213,0.00008492319,0.00004344837,0.00001518117,0.0001082822,0.0000594433,0.0000179791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006609676,"about_ca_system_score_gemma":0.0000787351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000689775,"about_ca_topic_score_gemma":0.000008186948,"domain_scores_codex":[0.9983236,0.00002987009,0.0004121785,0.0007387514,0.0001999299,0.0002957037],"domain_scores_gemma":[0.9993364,0.000007662933,0.00008399135,0.0003317228,0.0001166696,0.000123545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001235222,0.00004577979,0.01174523,0.00004532914,0.00004917085,0.000001080921,0.0002829041,0.00002390239,0.9627164,6.841763e-7,0.0003266502,0.02463934],"study_design_scores_gemma":[0.0003840258,0.00002108019,0.3667724,0.0000186891,0.000003756598,0.000008870702,0.00003049845,0.000003659853,0.6158891,0.000002918343,0.01670315,0.0001617964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764823,0.001004464,0.02159305,0.000313217,0.0003043683,0.0001986442,0.000004975025,0.0000564,0.00004263375],"genre_scores_gemma":[0.9952033,0.00008579738,0.002918266,0.00002405726,0.0002151377,0.00003856267,0.0001199246,0.00002177253,0.001373184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3550272,"threshold_uncertainty_score":0.7066401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007998385453010851,"score_gpt":0.2418763355962136,"score_spread":0.2338779501432028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}