{"id":"W2559734835","doi":"10.1071/rdv29n1ab1","title":"1 INSULIN TREATMENT DURING IN VITRO OOCYTE MATURATION LEADS TO DIFFERENT GENE EXPRESSION AND METHYLATION PATTERNS OF KEY GENES ASSOCIATED WITH METABOLISM AND STEROID SYNTHESIS IN THE BOVINE BLASTOCYST","year":2016,"lang":"en","type":"article","venue":"Reproduction Fertility and Development","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Epigenome; DNA methylation; Biology; Epigenetics; Transcriptome; Epigenomics; Oocyte; Hyperinsulinemia; Genetics; Blastocyst; Insulin; Methylation; Andrology; Bisulfite sequencing; Reproductive technology; Gene; Insulin resistance; Endocrinology; Gene expression; Embryo; Medicine; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006693729,0.0001649285,0.0003403955,0.0001313702,0.00008059856,0.000009099319,0.00002636479,0.00007731016,0.000004235405],"category_scores_gemma":[0.0003068325,0.00008285898,0.00001472124,0.0001026754,0.00006722964,0.0001070952,0.00003734625,0.00006378721,3.300115e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001411402,"about_ca_system_score_gemma":0.00003147528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003539864,"about_ca_topic_score_gemma":0.00009003051,"domain_scores_codex":[0.9984624,0.0002553954,0.0003717557,0.0006171613,0.0001508213,0.0001424015],"domain_scores_gemma":[0.9993966,0.00008559161,0.000104949,0.0002876592,0.0000750772,0.00005018017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01740407,0.000267069,0.2552563,0.00005618255,0.00003420432,0.000001882146,0.002328169,0.000001751174,0.6881016,3.796662e-7,1.823807e-7,0.03654817],"study_design_scores_gemma":[0.0006805282,0.00007838247,0.5253555,0.00007169424,0.00001522184,0.00000594921,0.00009504434,0.000001883948,0.4736234,0.00000591825,0.00001661298,0.0000498628],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969509,0.001072042,0.0002281881,0.0009728396,0.00003818872,0.0007128112,0.000008362313,0.00001408408,0.0000025686],"genre_scores_gemma":[0.9990898,0.0002597635,0.0004191494,0.00001254184,0.00002527542,0.0001350554,0.00001353103,0.000006302024,0.00003857517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2700992,"threshold_uncertainty_score":0.3378891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02327138076192845,"score_gpt":0.2442832654105008,"score_spread":0.2210118846485723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}