{"id":"W2559734835","doi":"10.1071/rdv29n1ab1","title":"1 INSULIN TREATMENT DURING IN VITRO OOCYTE MATURATION LEADS TO DIFFERENT GENE EXPRESSION AND METHYLATION PATTERNS OF KEY GENES ASSOCIATED WITH METABOLISM AND STEROID SYNTHESIS IN THE BOVINE BLASTOCYST","year":2016,"lang":"en","type":"article","venue":"Reproduction Fertility and Development","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Epigenome; DNA methylation; Biology; Epigenetics; Transcriptome; Epigenomics; Oocyte; Hyperinsulinemia; Genetics; Blastocyst; Insulin; Methylation; Andrology; Bisulfite sequencing; Reproductive technology; Gene; Insulin resistance; Endocrinology; Gene expression; Embryo; Medicine; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001896577,0.0002001375,0.0002854469,0.0001409473,0.0001690303,0.0003495485,0.0001611343,0.0001776042,0.002601896],"category_scores_gemma":[0.0001878229,0.0001761385,0.0002938445,0.0001863529,0.0001619434,0.00008335953,0.0001896957,0.0004447088,0.0005240259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001866428,"about_ca_system_score_gemma":0.000166769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001800556,"about_ca_topic_score_gemma":0.003653573,"domain_scores_codex":[0.9997562,0.00003373248,0.00002235357,0.00009404305,0.00005816905,0.00003550862],"domain_scores_gemma":[0.999908,0.00002040896,0.0000297808,0.00001156568,0.00001569083,0.00001446653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004081502,0.00002160622,0.001812673,0.00005202184,0.00001320899,0.00002855192,0.00003495813,0.0000348324,0.9955438,0.00001825743,0.0001069435,0.001925056],"study_design_scores_gemma":[0.0000673954,0.001068395,0.2230097,0.00004673416,0.0001745743,0.0002690168,0.0001563415,0.001092653,0.7621367,0.0001020998,0.01185496,0.00002141013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862319,0.002788125,0.003127424,0.00008866384,0.00009018567,0.0000476266,0.003668876,0.00008054978,0.003876769],"genre_scores_gemma":[0.9802824,0.001400752,0.004125373,0.0002338425,0.00001740951,0.0001229756,0.005897539,0.00007704699,0.007842748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002601896,"threshold_uncertainty_score":0.008704185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02327138076192845,"score_gpt":0.2442832654105008,"score_spread":0.2210118846485723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}