{"id":"W2559752444","doi":"10.1038/ncomms13788","title":"Transcriptional bursting is intrinsically caused by interplay between RNA polymerases on DNA","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; RIKEN","keywords":"Bursting; Biology; RNA; Transcriptional regulation; Polymerase; Cell biology; DNA; RNA polymerase; Gene; Gene expression; Genetics; Computational biology; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012941,0.0001568203,0.0001509568,0.0000629161,0.0001993684,0.00002004903,0.0008127874,0.0003183542,0.00004754774],"category_scores_gemma":[0.0001015624,0.0001221483,0.0001495552,0.000156361,0.0001544273,0.000005208995,0.000167441,0.0002773277,0.0000228473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003308382,"about_ca_system_score_gemma":0.00005160469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005091104,"about_ca_topic_score_gemma":0.00005926807,"domain_scores_codex":[0.9989982,0.0001356989,0.0002283221,0.0002832738,0.0001620404,0.0001925177],"domain_scores_gemma":[0.9981914,0.0001183077,0.0000922762,0.001391896,0.0001108207,0.00009535407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001712944,0.00008512606,0.007103175,0.000002152827,0.0002480636,2.302592e-7,0.00003227897,0.000002003149,0.9445534,0.0007242849,0.03471634,0.01251577],"study_design_scores_gemma":[0.0007539235,0.0001530167,0.02258683,0.0000705689,0.000156209,0.00000276537,0.00002574743,0.00003060447,0.514724,0.0001379821,0.4609482,0.0004102503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9636163,0.01047366,0.002028073,0.02118113,0.0001292118,0.0001852526,0.000424694,0.00005302697,0.001908634],"genre_scores_gemma":[0.9963039,0.000517117,0.0004901441,0.001130873,0.0002110723,0.00002011885,0.0004405907,0.00002359082,0.0008625544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4298295,"threshold_uncertainty_score":0.4981062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01300101972216928,"score_gpt":0.2907020532374798,"score_spread":0.2777010335153106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}