{"id":"W2559781323","doi":"10.1182/blood.v108.11.4393.4393","title":"Bortezomib Activity Against Mantle Cell Lymphoma Overcomes Classic Mechanisms of Drug Resistance and Targets Cell Cycle Control.","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Bortezomib; Mantle cell lymphoma; Proteasome inhibitor; Cyclin D1; Cancer research; Cell culture; Drug resistance; Cell cycle; Proteasome; Chemistry; Biology; Pharmacology; Cell; Lymphoma; Immunology; Biochemistry; Multiple myeloma; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001647257,0.0002544025,0.0003051013,0.0002256484,0.0001170634,0.0002297554,0.0001483733,0.000215087,0.001838889],"category_scores_gemma":[0.0001322189,0.0001206305,0.0001513075,0.0001839164,0.0001320818,0.0001592798,0.0001374558,0.0004504691,0.0003199229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002562831,"about_ca_system_score_gemma":0.0001220737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003968772,"about_ca_topic_score_gemma":0.001368818,"domain_scores_codex":[0.9998982,0.0000197727,0.000009724835,0.00001582992,0.00002766375,0.00002873265],"domain_scores_gemma":[0.9999417,0.00001260531,0.00001086992,0.00001059718,0.000006586705,0.0000177095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003353053,0.00008475163,0.0006809611,0.00009648407,0.00001645343,0.00004816001,0.000013276,0.0001026384,0.9894515,0.0001386821,0.0001706808,0.008861208],"study_design_scores_gemma":[0.0003037636,0.004596665,0.03102006,0.00003146851,0.00006326996,0.00116875,0.0000381991,0.001212399,0.948173,0.0001161695,0.01326937,0.000006938538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869832,0.008377367,0.0008340458,0.000142637,0.00006395393,0.00003982588,0.0004318416,0.0001269352,0.003000162],"genre_scores_gemma":[0.9957443,0.001303322,0.0007435115,0.00007397759,0.00002617642,0.00002232272,0.0007836938,0.00001007519,0.001292532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001838889,"threshold_uncertainty_score":0.006151736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003315730825562614,"score_gpt":0.190190651018684,"score_spread":0.1868749201931214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}