{"id":"W2559909514","doi":"10.1200/jco.2012.30.5_suppl.61","title":"Inhibition of Src and insulin/insulin-like growth factor-1 receptor (IR/IGF-1R) on tumors and bone turnover in prostate cancer (PCa) models in vivo compared with inhibition of either kinase alone.","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bone health and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Dasatinib; Proto-oncogene tyrosine-protein kinase Src; Medicine; Protein kinase B; Prostate cancer; Cancer research; Endocrinology; Internal medicine; Insulin-like growth factor; Bone remodeling; Phosphorylation; Growth factor; Cancer; Receptor; Chemistry; Tyrosine kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001993378,0.0004678252,0.000404312,0.0003242485,0.00010978,0.0002103439,0.0002098861,0.0002496478,0.001671773],"category_scores_gemma":[0.00008711045,0.000177952,0.0003971669,0.0002061412,0.0002440787,0.0002097467,0.0001108976,0.0008827262,0.0003297291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002630941,"about_ca_system_score_gemma":0.000427444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008398516,"about_ca_topic_score_gemma":0.00292452,"domain_scores_codex":[0.9998368,0.00002528289,0.00001034757,0.0000227192,0.00004934835,0.00005544486],"domain_scores_gemma":[0.9999291,0.00001222572,0.00001645446,0.000006619228,0.000006541014,0.0000290306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002244645,0.0009318772,0.0004627834,0.0001875513,0.000047199,0.00004235957,0.00001830557,0.0002403809,0.9877078,0.000122484,0.0003607465,0.007633829],"study_design_scores_gemma":[0.0003291847,0.01374732,0.01070084,0.00001476442,0.0001508832,0.0003692746,0.00002912642,0.0016379,0.9697519,0.00004828646,0.003210798,0.000009705812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920111,0.00418849,0.0007994987,0.0001823019,0.0001383405,0.00005329902,0.0003600353,0.0001304364,0.002136419],"genre_scores_gemma":[0.9932978,0.002372505,0.000930127,0.0000544814,0.00002565085,0.00007099427,0.0005852983,0.0000108002,0.002652439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001671773,"threshold_uncertainty_score":0.005592585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07637249769221782,"score_gpt":0.3871543825437267,"score_spread":0.3107818848515089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}