{"id":"W2559917577","doi":"10.1039/c6cc08549k","title":"High-resolution sub-cellular imaging by correlative NanoSIMS and electron microscopy of amiodarone internalisation by lung macrophages as evidence for drug-induced phospholipidosis","year":2016,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"","keywords":"Phospholipidosis; Correlative; Amiodarone; Electron microscope; Chemistry; Lung; Pathology; Drug; Biophysics; Medicine; Biology; Pharmacology; Biochemistry; Internal medicine; Optics; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001170021,0.0001444992,0.0001564114,0.00002112299,0.000103398,0.0000165649,0.000378461,0.00009920981,0.000004687502],"category_scores_gemma":[0.0001735978,0.0001198332,0.0000662188,0.00006089134,0.0002372096,0.00002023596,0.0001894883,0.00009375988,0.000001234042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005139702,"about_ca_system_score_gemma":0.0000358477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001215165,"about_ca_topic_score_gemma":0.000005561797,"domain_scores_codex":[0.9991497,0.00006408825,0.0002537232,0.000267178,0.00008334522,0.0001820127],"domain_scores_gemma":[0.9989132,0.0001328094,0.0001693423,0.0005882693,0.0001357641,0.00006056677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009067528,0.00005288666,0.0007670581,0.0000178581,0.00002523295,2.608675e-8,0.0000528234,5.719233e-8,0.994024,0.00005856462,0.003885519,0.001025343],"study_design_scores_gemma":[0.0006419761,0.00005954499,0.00007524368,0.00009377246,0.00007724803,0.000002384363,0.000021792,0.00002082455,0.9975209,0.0000603768,0.001277965,0.0001479582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910799,0.00480539,0.002528887,0.001069229,0.00006839721,0.0002919771,0.0001299871,0.00001229738,0.00001388457],"genre_scores_gemma":[0.9971325,0.001174136,0.0008402775,0.00009173957,0.00004444682,0.00008538626,0.0004448495,0.00001988847,0.0001667776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006052548,"threshold_uncertainty_score":0.4886656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01271497016026076,"score_gpt":0.3073111768227305,"score_spread":0.2945962066624697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}