{"id":"W2559924710","doi":"10.1039/c6sc03993f","title":"Complementary oligonucleotides regulate induced fit ligand binding in duplexed aptamers","year":2016,"lang":"en","type":"article","venue":"Chemical Science","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University and Génome Québec Innovation Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Aptamer; Oligonucleotide; Ligand (biochemistry); Computational biology; Computer science; Chemistry; Biology; Combinatorial chemistry; Genetics; Receptor; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002282012,0.0001908465,0.0002087037,0.0001459374,0.00009655941,0.0003637525,0.0001688557,0.000276937,0.001459838],"category_scores_gemma":[0.0006391125,0.0001334867,0.0001375195,0.00007971191,0.0002618855,0.0002078351,0.0002219209,0.0003600341,0.0004709609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002565748,"about_ca_system_score_gemma":0.0001504557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001603771,"about_ca_topic_score_gemma":0.0003624371,"domain_scores_codex":[0.9996942,0.00006600564,0.00001813532,0.00009571278,0.00008441622,0.0000416084],"domain_scores_gemma":[0.9996048,0.0001727793,0.00007607071,0.00002473671,0.00005407386,0.00006756571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002274202,0.00001420537,0.00008820713,0.00001100901,0.000001505328,0.00001096232,0.00001399879,0.00005219202,0.9987901,0.000120895,0.00001049743,0.0008636098],"study_design_scores_gemma":[0.000003711913,0.0001104148,0.0006621709,0.000001346503,0.000002092933,0.00004317064,0.0000105248,0.001065786,0.9975221,0.0000466204,0.0005293804,0.000002625968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841718,0.0004382361,0.01307881,0.00004459278,0.00003368497,0.00004175937,0.00006879424,0.0001254888,0.001996859],"genre_scores_gemma":[0.9925708,0.0001240971,0.005391407,0.00005283048,0.000006370084,0.00002525419,0.00006944369,0.00001790753,0.001741885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001459838,"threshold_uncertainty_score":0.004883647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02233130492639446,"score_gpt":0.2974064898709722,"score_spread":0.2750751849445778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}