{"id":"W2560005855","doi":"10.1016/j.it.2016.11.005","title":"T Cell Exhaustion in Glioblastoma: Intricacies of Immune Checkpoints","year":2016,"lang":"en","type":"review","venue":"Trends in Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canada Research Chairs; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Immune system; Immunology; Glioblastoma; Medicine; Biology; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004282778,0.0004239044,0.0024814,0.002550778,0.00001699423,0.000004297086,0.0002986547,0.0007513948,0.001096485],"category_scores_gemma":[0.0000539494,0.0003065048,0.0005801351,0.001570959,0.0003512144,0.00005535323,0.0001153551,0.0005938587,0.00007107618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005406297,"about_ca_system_score_gemma":0.0002305496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001728859,"about_ca_topic_score_gemma":0.00004790317,"domain_scores_codex":[0.9972223,0.0002149378,0.001548368,0.0004245045,0.0001505658,0.0004393018],"domain_scores_gemma":[0.9984501,0.000167163,0.0006603383,0.0006530851,0.00004203459,0.00002725646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001069946,0.0002978868,0.00002830694,0.00265452,0.0002024768,0.00005675086,0.000107338,3.309248e-8,0.0006634445,0.00002759999,0.0002163123,0.9946754],"study_design_scores_gemma":[0.005565177,0.0009947298,0.001586326,0.01983031,0.000254594,0.0002330964,0.00005050377,4.394175e-7,0.0008350387,0.0000241561,0.9702389,0.0003867406],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001056877,0.9951769,0.000002443013,0.00009216165,0.0005251214,0.0003146722,0.00002688064,0.00003038551,0.002774612],"genre_scores_gemma":[0.002334298,0.9939845,0.00004840803,0.00001087294,0.00006018075,0.0001058251,0.00005503978,0.00005140712,0.003349428],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9942886,"threshold_uncertainty_score":0.9999387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02997503648571365,"score_gpt":0.3369090748250731,"score_spread":0.3069340383393594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}