{"id":"W2560029808","doi":"10.1039/c6md00565a","title":"Development of new scaffolds as reversible tissue transglutaminase inhibitors, with improved potency or resistance to glutathione addition","year":2016,"lang":"en","type":"article","venue":"MedChemComm","topic":"Blood properties and coagulation","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies; Universities Space Research Association; Fonds de recherche du Québec – Nature et technologies; University of Ottawa","keywords":"Tissue transglutaminase; Glutathione; Potency; Chemistry; Biochemistry; Combinatorial chemistry; Pharmacology; Biophysics; Enzyme; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001562655,0.00015857,0.000274353,0.00008464424,0.00007440808,0.000007157915,0.00008420608,0.00008871868,0.0006784786],"category_scores_gemma":[0.00005210189,0.00008947276,0.00003276976,0.0002759869,0.0000355195,0.0001194123,0.00002468801,0.00004590336,0.00005432498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001029645,"about_ca_system_score_gemma":0.0004389398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006650015,"about_ca_topic_score_gemma":0.0004054382,"domain_scores_codex":[0.9988579,0.00001834072,0.000336354,0.0002562533,0.0003103419,0.0002208759],"domain_scores_gemma":[0.9992321,0.0000247915,0.00009537111,0.0002913925,0.0001317749,0.0002246352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003461591,0.0001805882,0.0001343743,0.0002056885,0.00006647067,0.00002281841,0.002281917,3.23527e-7,0.7010989,0.00006039566,0.009087059,0.2833999],"study_design_scores_gemma":[0.002330424,0.0006739518,0.001624593,0.001204335,0.00007457113,0.00002074681,0.0002545962,0.000001889194,0.8754272,0.00004451786,0.1181724,0.0001708432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814713,0.0003167958,0.005557023,0.009653133,0.00009535231,0.0007917238,0.00001416188,0.00008397629,0.002016504],"genre_scores_gemma":[0.9104362,0.00002231434,0.05224828,0.0003050907,0.000128956,0.00003699882,0.00002325302,0.00002893639,0.03676994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.283229,"threshold_uncertainty_score":0.7428865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01864182153567226,"score_gpt":0.2515518589228394,"score_spread":0.2329100373871671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}