{"id":"W2560044495","doi":"10.1073/pnas.1617824113","title":"Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Janssen Research and Development; Vetenskapsrådet; Fondation Brain Canada; Knut och Alice Wallenbergs Stiftelse; Magyar Tudományos Akadémia; AFA Försäkring; Semmelweis Egyetem; Svenska Forskningsrådet Formas; Karolinska Institutet; Marcus och Amalia Wallenbergs minnesfond; McLean Hospital; European Commission; Johns Hopkins University; Stockholms Universitet; University of Oxford","keywords":"Galanin; Dorsal raphe nucleus; Locus coeruleus; Galanin receptor; Neuropeptide; Major depressive disorder; DNA methylation; Internal medicine; Endocrinology; Methylation; Receptor; Biology; Mood disorders; Medicine; Serotonin; Central nervous system; Genetics; Gene; Psychiatry; Gene expression; Serotonergic","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006898423,0.00008955215,0.0001584237,0.0001649305,0.0001172899,0.0000174207,0.0006439248,0.00003501639,0.000004001073],"category_scores_gemma":[0.0008444178,0.00004330196,0.00004171641,0.0006974027,0.0007927129,0.0004880352,0.00008033149,0.0001192849,6.311007e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001245313,"about_ca_system_score_gemma":0.00001984079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002118009,"about_ca_topic_score_gemma":0.000001936401,"domain_scores_codex":[0.9985872,0.00005663518,0.0004050863,0.0002786269,0.0005330938,0.0001393597],"domain_scores_gemma":[0.9990338,0.0005166958,0.0003265447,0.00001298122,0.00009277621,0.00001717307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001568921,0.00002821385,0.006923541,0.00004146696,0.000001066997,2.862095e-8,0.0003774295,0.00003812422,0.9148577,0.07752963,0.00003096349,0.0001561878],"study_design_scores_gemma":[0.0003694432,0.00007043444,0.3902603,0.0001998678,0.000004956181,0.00001011393,0.000341312,0.000299513,0.5957405,0.0125793,0.00005947361,0.00006479432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963443,0.00004672922,0.000001915777,0.001638668,0.00001094585,0.0002386705,0.00003246773,0.000004778836,0.001681492],"genre_scores_gemma":[0.9995088,0.00002887225,0.00008462458,0.0002935362,0.00002083358,0.00001436056,2.233771e-8,0.000004029035,0.00004494335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3833368,"threshold_uncertainty_score":0.2920784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06465808068392467,"score_gpt":0.2964655590287971,"score_spread":0.2318074783448724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}