{"id":"W2560044495","doi":"10.1073/pnas.1617824113","title":"Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Janssen Research and Development; Vetenskapsrådet; Fondation Brain Canada; Knut och Alice Wallenbergs Stiftelse; Magyar Tudományos Akadémia; AFA Försäkring; Semmelweis Egyetem; Svenska Forskningsrådet Formas; Karolinska Institutet; Marcus och Amalia Wallenbergs minnesfond; McLean Hospital; European Commission; Johns Hopkins University; Stockholms Universitet; University of Oxford","keywords":"Galanin; Dorsal raphe nucleus; Locus coeruleus; Galanin receptor; Neuropeptide; Major depressive disorder; DNA methylation; Internal medicine; Endocrinology; Methylation; Receptor; Biology; Mood disorders; Medicine; Serotonin; Central nervous system; Genetics; Gene; Psychiatry; Gene expression; Serotonergic","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009025801,0.0001454781,0.00009398221,0.0002548307,0.00009701202,0.0001433257,0.00007898748,0.0001778323,0.001044571],"category_scores_gemma":[0.0001831971,0.00008795248,0.00009794255,0.0001017392,0.0002095368,0.00006386275,0.0001254665,0.0003262846,0.0001409659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001116829,"about_ca_system_score_gemma":0.00007760149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000425964,"about_ca_topic_score_gemma":0.0008295769,"domain_scores_codex":[0.9999437,0.00001166136,0.000003889386,0.0000170737,0.00001356341,0.0000100302],"domain_scores_gemma":[0.9999305,0.0000120105,0.00002729619,0.000006278699,0.000009451755,0.00001450691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003387431,0.00002799049,0.02962491,0.00004205719,0.00005442008,0.0001418106,0.00008172095,0.0000663051,0.9601445,0.00006532061,0.00007251851,0.009339704],"study_design_scores_gemma":[0.00001799442,0.0003849806,0.8639365,0.00001164727,0.00006720993,0.001699631,0.0001695106,0.0004431243,0.1319193,0.000444016,0.0008987903,0.000007307863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968908,0.0008773935,0.001233145,0.0000957078,0.000009393217,0.00000763099,0.0003071272,0.00002053119,0.0005582605],"genre_scores_gemma":[0.9984068,0.0002799342,0.0005479484,0.00004530041,0.000003010203,0.000007605403,0.0001549955,0.00000361815,0.0005508167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001044571,"threshold_uncertainty_score":0.003494442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06465808068392467,"score_gpt":0.2964655590287971,"score_spread":0.2318074783448724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}