{"id":"W2560056817","doi":"10.1182/blood.v128.22.3107.3107","title":"Safety and Efficacy of Ruxolitinib for the Final Enrollment of JUMP: An Open-Label, Multicenter, Single-Arm, Expanded-Access Study in Patients with Myelofibrosis (N = 2233)","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Ruxolitinib; Medicine; Myelofibrosis; Internal medicine; Tolerability; Clinical endpoint; Discontinuation; Phases of clinical research; Clinical trial; Adverse effect; Expanded access; Placebo; Surgery; Bone marrow; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002542423,0.0005722975,0.001016508,0.0002971191,0.0004035323,0.00106464,0.000486442,0.0007803913,0.002911363],"category_scores_gemma":[0.001855806,0.000334908,0.001333308,0.0005665481,0.0005120419,0.000765603,0.00062703,0.001257008,0.0006629988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000670541,"about_ca_system_score_gemma":0.001298833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008835025,"about_ca_topic_score_gemma":0.002147918,"domain_scores_codex":[0.999209,0.0003484669,0.00005905264,0.0001366051,0.0001443474,0.000102525],"domain_scores_gemma":[0.998531,0.0001904284,0.0004770425,0.0001254281,0.0001456245,0.000530451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7398776,0.01543049,0.1561716,0.0006027194,0.00248693,0.0004354842,0.0003298094,0.001474287,0.01467879,0.0001630291,0.005122717,0.06322647],"study_design_scores_gemma":[0.2638972,0.1859862,0.5323407,0.0001009634,0.003446854,0.0007864053,0.0002567013,0.003418742,0.004038651,0.0002185794,0.005410433,0.00009846321],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968756,0.0003291671,0.00015555,0.00009349803,0.00001833072,0.0005522296,0.001171952,0.00003338114,0.0007702386],"genre_scores_gemma":[0.9940574,0.0001874473,0.0004295603,0.0002457623,0.00006100892,0.0006717861,0.003760144,0.00001335999,0.0005733898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002911363,"threshold_uncertainty_score":0.01344579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0618019106275395,"score_gpt":0.3331993970182839,"score_spread":0.2713974863907444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}