{"id":"W2560062929","doi":"10.1124/pr.116.012989","title":"The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9","year":2016,"lang":"en","type":"review","venue":"Pharmacological Reviews","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"PCSK9; Kexin; Proprotein convertase; Proprotein Convertases; LDL receptor; Furin; Subtilisin; Biology; Familial hypercholesterolemia; Cell biology; Biochemistry; Cholesterol; Lipoprotein; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004066266,0.001010077,0.001515106,0.002064577,0.0002209478,0.0008324478,0.0007388893,0.0008204741,0.004298211],"category_scores_gemma":[0.0004778108,0.0002732969,0.000491182,0.002197261,0.0003621783,0.001154882,0.0007369628,0.001969619,0.002456342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003746827,"about_ca_system_score_gemma":0.0008826518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006149951,"about_ca_topic_score_gemma":0.001402336,"domain_scores_codex":[0.9998548,0.00001765067,0.00002442611,0.00002267268,0.00006188088,0.0000185442],"domain_scores_gemma":[0.9997914,0.00007572522,0.0000389398,0.000005991052,0.00006073387,0.00002710853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001770961,0.0001049661,0.0001076701,0.0171471,0.0001301735,0.0002097744,0.00004020284,0.0002443098,0.005098312,0.002173423,0.04464636,0.9299207],"study_design_scores_gemma":[0.00005748038,0.0001384861,0.0007198301,0.002394531,0.0001769516,0.001030944,0.00003675356,0.00009057726,0.0006545733,0.001424206,0.9932535,0.00002221707],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007556927,0.9987416,0.0001334338,0.000144091,0.0002652213,0.00000425519,0.00001768867,0.00000708958,0.0006110172],"genre_scores_gemma":[0.0003931622,0.998256,0.0002118922,0.0001535,0.0002944411,0.000005113939,0.00003515823,0.000001415039,0.0006492031],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004298211,"threshold_uncertainty_score":0.01437896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04808997476886261,"score_gpt":0.3452143599684819,"score_spread":0.2971243851996193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}