{"id":"W2560068008","doi":"10.1091/mbc.e16-06-0453","title":"C-terminus of the P4-ATPase ATP8A2 functions in protein folding and regulation of phospholipid flippase activity","year":2016,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Eye Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Flippase; Phosphatidylserine; Biology; Endoplasmic reticulum; Phosphatidylethanolamine; Biochemistry; Cell biology; Translocase; Phosphorylation; ATPase; C-terminus; Protein folding; Phospholipid; Membrane; Amino acid; Enzyme; Phosphatidylcholine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382005,0.0001106254,0.0001648781,0.0000319436,0.00003234491,0.000001339013,0.0001981975,0.0001625046,0.00000921349],"category_scores_gemma":[0.00006399814,0.00005848249,0.0001227942,0.00009500906,0.0003062037,0.000003185811,0.0001868558,0.00005944202,2.413445e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007347076,"about_ca_system_score_gemma":0.00005275334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005908167,"about_ca_topic_score_gemma":0.00002496333,"domain_scores_codex":[0.9992481,0.0001489843,0.000201073,0.0002086185,0.00006422802,0.0001289637],"domain_scores_gemma":[0.9992286,0.0000128429,0.0002236822,0.0004636513,0.00004915791,0.0000220791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008426538,0.00005089612,0.007221822,0.0000336481,0.00001316236,3.084438e-7,0.00001353024,0.000005820178,0.9907649,0.00004811325,0.00001502016,0.001748565],"study_design_scores_gemma":[0.0006040889,0.0001289842,0.0166652,0.00004107685,0.00003277976,0.000005217595,0.00000618574,0.000002490384,0.9820209,0.00009847831,0.0003229182,0.00007167849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987639,0.0001286739,0.000313576,0.0001891198,0.0001444205,0.0003101697,0.00003741993,0.000002025401,0.0001107638],"genre_scores_gemma":[0.9994553,0.000009876059,0.00009911215,0.00002444818,0.0000253609,0.0000127199,0.000004317693,0.000009653041,0.0003592242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009443373,"threshold_uncertainty_score":0.2384847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005006156485662588,"score_gpt":0.218465106349627,"score_spread":0.2134589498639644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}