{"id":"W2560077369","doi":"10.1038/cddiscovery.2016.70","title":"Mitochondrial permeability transition pore induction is linked to formation of the complex of ATPase C-subunit, polyhydroxybutyrate and inorganic polyphosphate","year":2016,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of General Medical Sciences; Heart and Stroke Foundation of Canada; American Heart Association","keywords":"MPTP; Mitochondrial permeability transition pore; Uniporter; Mitochondrion; Cell biology; Polyphosphate; Chemistry; Protein subunit; Polyhydroxybutyrate; Biochemistry; Biophysics; Ruthenium red; Inner mitochondrial membrane; Calcium; Biology; Programmed cell death; Cytosol; Phosphate; Apoptosis; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001092817,0.0002092736,0.0001512904,0.0001415758,0.0001099947,0.0002467506,0.00015042,0.0002341729,0.0008995883],"category_scores_gemma":[0.0001716264,0.0001374066,0.0001771433,0.0001126964,0.0002576313,0.0002405413,0.000173174,0.0004889246,0.000206009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002895954,"about_ca_system_score_gemma":0.0001093823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002776633,"about_ca_topic_score_gemma":0.0002235067,"domain_scores_codex":[0.9998826,0.00001639427,0.0000109354,0.00003186151,0.00003014226,0.00002807133],"domain_scores_gemma":[0.9997522,0.00003025626,0.0001160312,0.00002136551,0.00002109707,0.00005892853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008219381,0.00001189884,0.0001674842,0.00001237711,0.000002771719,0.00007021705,0.000003793382,0.000009936999,0.999361,0.00005203781,0.00001073712,0.0002156039],"study_design_scores_gemma":[0.00001192245,0.0001417476,0.008119368,0.000002672463,0.000007631711,0.0007271817,0.00001179643,0.0003673233,0.9899353,0.00006468187,0.0006084494,0.000001805432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944365,0.001118946,0.003468493,0.0001071078,0.00003218231,0.00002280584,0.0001541621,0.00007551289,0.0005843446],"genre_scores_gemma":[0.9977901,0.0003923428,0.0008565363,0.00001690006,0.00001038272,0.00001234731,0.0001804765,0.000007359539,0.0007336694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008995883,"threshold_uncertainty_score":0.003009379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01547684567605783,"score_gpt":0.2258928772533244,"score_spread":0.2104160315772666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}