{"id":"W2560110452","doi":"10.1002/jat.3420","title":"Responses of A549 human lung epithelial cells to cristobalite and α‐quartz exposures assessed by toxicoproteomics and gene expression analysis","year":2016,"lang":"en","type":"article","venue":"Journal of Applied Toxicology","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"Health Canada; Clean Air Regulatory Agenda","keywords":"Cytotoxicity; Gene expression; A549 cell; Molecular biology; Programmed cell death; Biology; Apoptosis; Lactate dehydrogenase; Cell; Chemistry; Cell biology; Gene; Biochemistry; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001258317,0.0003438075,0.0002743882,0.0002842877,0.0002079027,0.0002521459,0.00009301678,0.0003379819,0.0005953109],"category_scores_gemma":[0.0001459111,0.0001376599,0.0003052904,0.0002739483,0.0002028169,0.0001813916,0.0001866211,0.0002587477,0.0002008921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001776841,"about_ca_system_score_gemma":0.0001622197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001023941,"about_ca_topic_score_gemma":0.001515833,"domain_scores_codex":[0.9998032,0.00002187555,0.00001663537,0.00005257298,0.00007404715,0.00003166923],"domain_scores_gemma":[0.9999064,0.00001731522,0.0000230089,0.000007243766,0.00003526687,0.0000107245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002829946,0.000006768456,0.0003398122,0.00002100464,0.00000327998,0.0000195666,0.00001237805,0.00001855682,0.9992211,0.000005949259,0.000005065193,0.0003181049],"study_design_scores_gemma":[0.000005957224,0.0003145848,0.04251016,0.000005204311,0.00002494446,0.0002185102,0.0001237363,0.0007268423,0.9549887,0.00004061275,0.00103349,0.000007314421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917228,0.001820167,0.004165663,0.0001170089,0.00003149607,0.00007894458,0.0009043405,0.00003827663,0.001121419],"genre_scores_gemma":[0.9831426,0.002619405,0.008426226,0.0002485106,0.00002638306,0.0002803093,0.001954685,0.00001541789,0.003286404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001023941,"threshold_uncertainty_score":0.002035975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008262070458905318,"score_gpt":0.2725608702716185,"score_spread":0.2642987998127131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}