{"id":"W2560113261","doi":"10.1002/humu.23152","title":"SLC4A11 Three-Dimensional Homology Model Rationalizes Corneal Dystrophy-Causing Mutations","year":2016,"lang":"en","type":"article","venue":"Human Mutation","topic":"Photosynthetic Processes and Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Mutant; Homology modeling; Transmembrane domain; Point mutation; Genetics; Corneal endothelium; Transport protein; Cell biology; Gene; Biochemistry; Endothelium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009080733,0.0003884509,0.0003379464,0.0002055283,0.0004021763,0.0005086299,0.0004877037,0.0004995596,0.002556449],"category_scores_gemma":[0.0001824324,0.0001590714,0.0003835846,0.000153035,0.0001900203,0.0002431016,0.0002366723,0.0003235124,0.0004203652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007493107,"about_ca_system_score_gemma":0.0006723566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005131983,"about_ca_topic_score_gemma":0.003251966,"domain_scores_codex":[0.9999449,0.00001123419,0.000002786119,0.00000864581,0.00002015409,0.00001228578],"domain_scores_gemma":[0.9999425,0.00001532187,0.00001210685,0.000004220869,0.00001141413,0.00001426862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0007599751,0.0003154896,0.004066754,0.0002641568,0.0000959796,0.002087175,0.0002508073,0.7579821,0.1872365,0.03529201,0.002190942,0.009458092],"study_design_scores_gemma":[0.0001262539,0.0002105822,0.0008764221,0.00001734994,0.00002998112,0.0002570941,0.00009564342,0.9786413,0.01172236,0.003515322,0.004489772,0.00001789643],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9397735,0.0003589964,0.04922112,0.0003805498,0.00004676538,0.00008200882,0.0009723366,0.0006632116,0.008501581],"genre_scores_gemma":[0.9782977,0.0002243503,0.01885558,0.00003272015,0.000005967254,0.00006605504,0.001082503,0.00007559653,0.001359545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005131983,"threshold_uncertainty_score":0.01020426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02100422324830229,"score_gpt":0.2688113221280088,"score_spread":0.2478070988797065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}