{"id":"W2560135976","doi":"10.1681/asn.2016010069","title":"Genetic Variants Associated with Circulating Parathyroid Hormone","year":2016,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Center for Research Resources; U.S. National Library of Medicine; National Institute of General Medical Sciences; National Human Genome Research Institute; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institutes of Health; Ministry of Cultural Affairs; Roche Diabetes Care; Abbott Diabetes Care; Universitair Medisch Centrum Groningen; Göteborgs Läkaresällskap; Siemens; Vetenskapsrådet; Novo Nordisk; Bundesministerium für Bildung und Forschung; Vrije Universiteit Amsterdam; Stiftelsen för Strategisk Forskning; National Center for Advancing Translational Sciences; Leids Universitair Medisch Centrum; Universiteit Leiden; Insulet Corporation; Nipro; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; European Commission; Universität Greifswald; Johns Hopkins University; Eli Lilly and Company; Novo Nordisk Fonden; Foundation for the National Institutes of Health","keywords":"Parathyroid hormone; CYP24A1; Single-nucleotide polymorphism; Internal medicine; Endocrinology; Vitamin D and neurology; Minor allele frequency; Biology; Secondary hyperparathyroidism; SNP; Calcitriol receptor; Medicine; Genotype; Genetics; Calcium; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002676243,0.000115917,0.0002951435,0.00001574616,0.00006136059,0.000005328066,0.0003161924,0.00006648774,0.000005120562],"category_scores_gemma":[0.0001008413,0.00006187043,0.0002755565,0.0001392008,0.0004521126,0.000003432261,0.0001126997,0.00009458889,6.901581e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001952068,"about_ca_system_score_gemma":0.0001078624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001326643,"about_ca_topic_score_gemma":0.000002788935,"domain_scores_codex":[0.9989779,0.0001252806,0.0003475263,0.00013838,0.0001753995,0.000235527],"domain_scores_gemma":[0.9982827,0.00005438436,0.001178482,0.0002483395,0.0001813597,0.00005478919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003272523,0.00003720601,0.01644588,0.00000163307,0.0003389348,0.00000127236,0.00006723892,0.00007125059,0.9764915,0.000001354128,0.00328774,0.003223246],"study_design_scores_gemma":[0.0009987943,0.001486291,0.9872022,0.00002429396,0.000071658,0.000443442,0.0001430708,0.00004131037,0.007579963,0.00007714168,0.001825725,0.0001060981],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947608,0.0003725335,0.003589723,0.001149663,0.00003530939,0.00005592804,0.000003521664,0.000002040024,0.00003049942],"genre_scores_gemma":[0.9934917,0.0003034767,0.004731939,0.001224463,0.000158317,0.000001114335,3.414902e-7,0.00001677669,0.00007186985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9707564,"threshold_uncertainty_score":0.2523003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009539322404251978,"score_gpt":0.2285852197111719,"score_spread":0.2190458973069199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}