{"id":"W2560187753","doi":"10.1172/jci88648","title":"Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Prohormone convertase; Endocrinology; Prohormone; Internal medicine; Biology; Proinsulin; Knockout mouse; Hormone; Gene; Medicine; Insulin; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008094047,0.000554546,0.0002317527,0.0003913514,0.00015824,0.0002513384,0.0002193007,0.0003578124,0.002256298],"category_scores_gemma":[0.0001409949,0.0002533592,0.0002780511,0.0001261142,0.0003799075,0.0001803471,0.0002989977,0.0006145551,0.0004133047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001881216,"about_ca_system_score_gemma":0.0001752366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006694012,"about_ca_topic_score_gemma":0.001314799,"domain_scores_codex":[0.999867,0.00001377513,0.00002470234,0.0000369423,0.00003796492,0.0000195956],"domain_scores_gemma":[0.9998382,0.00002345424,0.00005419782,0.00001400554,0.000006293832,0.00006373073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001468724,0.00003167832,0.0003930285,0.00002283223,0.000008891215,0.0002092018,0.00001672071,0.00004619845,0.9982017,0.00004211386,0.00002549263,0.0008551761],"study_design_scores_gemma":[0.00006604288,0.0005524856,0.02575474,0.00001140808,0.00005410761,0.002136672,0.00005861093,0.001065013,0.9682019,0.00007867394,0.002008643,0.00001164664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979353,0.0003053818,0.0008867442,0.00004676701,0.00002199133,0.00001304394,0.0003953845,0.00005708655,0.0003381952],"genre_scores_gemma":[0.994971,0.0005135072,0.001254836,0.00004597862,0.000007153283,0.00002299869,0.0006353964,0.00003434899,0.002514654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002256298,"threshold_uncertainty_score":0.007548094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0408665860268086,"score_gpt":0.3312495679486059,"score_spread":0.2903829819217973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}