{"id":"W2560310448","doi":"10.1681/asn.2016020169","title":"Intercalated Cell Depletion and Vacuolar H+-ATPase Mistargeting in an Ae1 R607H Knockin Model","year":2016,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agence Nationale de la Recherche","keywords":"Intercalated Cell; Distal renal tubular acidosis; Band 3; V-ATPase; Epithelial polarity; Cell biology; Secretion; Biology; Intracellular pH; Nephron; ATPase; Intracellular; Chemistry; Molecular biology; Internal medicine; Endocrinology; Biochemistry; Kidney; Cell; Membrane protein; Metabolic acidosis; Membrane; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002462074,0.00008130589,0.0001808868,0.00002385042,0.00003007425,0.000003048774,0.0001391079,0.00007723869,0.000003259195],"category_scores_gemma":[0.000009348696,0.00005075962,0.0001463165,0.0000683028,0.00024032,0.000009266223,0.00003049302,0.00009007059,1.318378e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001623098,"about_ca_system_score_gemma":0.00004260976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001575877,"about_ca_topic_score_gemma":0.00001652056,"domain_scores_codex":[0.9993179,0.00008094342,0.0002801338,0.000110233,0.00008361905,0.0001272117],"domain_scores_gemma":[0.9992894,0.00001298735,0.0004389687,0.0001174673,0.00009930394,0.00004186311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002434964,0.00005041696,0.0127763,0.000007691621,0.0000227215,6.265685e-7,0.0002357711,0.000447416,0.984243,0.000002425803,0.0007227435,0.001247391],"study_design_scores_gemma":[0.0052479,0.003453349,0.4090716,0.0001249568,0.0001509343,0.0001467563,0.001914913,0.01655842,0.5531761,0.001100582,0.008550662,0.000503843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921839,0.0001447598,0.006119759,0.001469362,0.00002855023,0.00004218031,0.000003598783,0.000001632656,0.000006303663],"genre_scores_gemma":[0.9969497,0.000287636,0.001793804,0.0008255008,0.0000904747,7.447964e-7,0.00000283135,0.000009794922,0.00003947292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4310669,"threshold_uncertainty_score":0.2069917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009128459575071662,"score_gpt":0.2357737049504065,"score_spread":0.2266452453753349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}