{"id":"W2560310448","doi":"10.1681/asn.2016020169","title":"Intercalated Cell Depletion and Vacuolar H+-ATPase Mistargeting in an Ae1 R607H Knockin Model","year":2016,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agence Nationale de la Recherche","keywords":"Intercalated Cell; Distal renal tubular acidosis; Band 3; V-ATPase; Epithelial polarity; Cell biology; Secretion; Biology; Intracellular pH; Nephron; ATPase; Intracellular; Chemistry; Molecular biology; Internal medicine; Endocrinology; Biochemistry; Kidney; Cell; Membrane protein; Metabolic acidosis; Membrane; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005577652,0.001044117,0.0008547592,0.001292258,0.0004850728,0.0006207435,0.0006294808,0.001507162,0.003124924],"category_scores_gemma":[0.0003447516,0.0005468055,0.0007294817,0.0003654982,0.0009305426,0.0005839997,0.0005967896,0.001344486,0.000872255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005659331,"about_ca_system_score_gemma":0.0002943557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006293893,"about_ca_topic_score_gemma":0.0007414183,"domain_scores_codex":[0.9994637,0.00007259009,0.00007868631,0.0001743152,0.0001128973,0.00009777897],"domain_scores_gemma":[0.9991997,0.000120498,0.0002665248,0.00007933462,0.00004605798,0.0002878162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007249065,0.0003078416,0.0002538119,0.00006333399,0.00001928882,0.0006272858,0.00005019696,0.0001572396,0.9962858,0.0004505539,0.0001007159,0.0009589727],"study_design_scores_gemma":[0.0005143568,0.004215095,0.00773583,0.00006388561,0.0002179548,0.004056174,0.00016554,0.005931516,0.9707451,0.0005218644,0.005780965,0.00005176506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914437,0.0007603571,0.004813683,0.000281693,0.0001079739,0.0001533447,0.0009236507,0.0003265845,0.001188975],"genre_scores_gemma":[0.9840133,0.001067952,0.005454502,0.0001795873,0.0000513949,0.0002803326,0.001036836,0.000171683,0.007744329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003124924,"threshold_uncertainty_score":0.01045388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009128459575071662,"score_gpt":0.2357737049504065,"score_spread":0.2266452453753349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}