{"id":"W2560364466","doi":"10.2196/resprot.6559","title":"Data Analysis Protocol for the Development and Evaluation of Population Pharmacokinetic Models for Incorporation Into the Web-Accessible Population Pharmacokinetic Service - Hemophilia (WAPPS-Hemo)","year":2016,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University; University of Waterloo","funders":"","keywords":"Protocol (science); Pharmacokinetics; Population; Population pharmacokinetics; Service (business); Medicine; Computer science; Pharmacology; Alternative medicine; Environmental health; Business","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04587235,0.001693221,0.001805675,0.002237092,0.001509533,0.003296114,0.00252835,0.002254583,0.1310141],"category_scores_gemma":[0.107908,0.001436652,0.002938231,0.002372213,0.001117654,0.001730417,0.003013773,0.004888263,0.0424106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002993118,"about_ca_system_score_gemma":0.02110679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004551743,"about_ca_topic_score_gemma":0.004711307,"domain_scores_codex":[0.980493,0.007989787,0.005082982,0.00260117,0.00324346,0.0005897104],"domain_scores_gemma":[0.9053583,0.04290231,0.005907921,0.01896884,0.02478015,0.002082499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.006600673,0.0009750559,0.007838975,0.01007474,0.0006074342,0.0005257208,0.001134677,0.007017624,0.004431588,0.0190686,0.6851729,0.2565521],"study_design_scores_gemma":[0.004510064,0.0007547261,0.01107098,0.004950705,0.0002823497,0.0002208546,0.0003502127,0.009975614,0.006816221,0.01962918,0.9412048,0.0002343466],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"protocol","genre_scores_codex":[0.003784851,0.000465139,0.2043747,0.002200882,0.0009491387,0.1676843,0.589898,0.01630714,0.0143358],"genre_scores_gemma":[0.01167415,0.000404834,0.2473691,0.002126312,0.0002072658,0.5630007,0.165963,0.002458374,0.006796277],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.1310141,"threshold_uncertainty_score":0.4382858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5458424917630936,"score_gpt":0.6118986636784347,"score_spread":0.06605617191534108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}