{"id":"W2560432428","doi":"10.21037/tlcr.2016.09.05","title":"Are immune checkpoint blockade monoclonal antibodies active against CNS metastases from NSCLC?—current evidence and future perspectives","year":2016,"lang":"en","type":"review","venue":"Translational Lung Cancer Research","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Blockade; Oncology; Immunotherapy; Monoclonal antibody; Immune checkpoint; Lung cancer; Disease; Immune system; Internal medicine; Clinical trial; Pembrolizumab; Atezolizumab; PD-L1; Targeted therapy; Antibody; Cancer; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008033936,0.0006642474,0.001899631,0.0005051657,0.0003814249,0.00008862825,0.0002606046,0.0002426857,0.001048345],"category_scores_gemma":[0.0001406044,0.0004289404,0.0007634599,0.0004861736,0.0005236205,0.0002335642,0.0001059317,0.001297623,0.00003159221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007090553,"about_ca_system_score_gemma":0.001650593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002675688,"about_ca_topic_score_gemma":0.00008327542,"domain_scores_codex":[0.9951333,0.0007575636,0.0007172573,0.001163082,0.001557079,0.0006716968],"domain_scores_gemma":[0.9965106,0.001649056,0.0003675362,0.0005219821,0.0006140549,0.0003367581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005060513,0.000331312,0.0002353747,0.007873764,0.003340162,0.0001140112,0.0007452433,0.000001000619,0.00003716522,0.0002822425,0.0002876467,0.986246],"study_design_scores_gemma":[0.002069263,0.0001697354,0.009653835,0.08521728,0.003292057,0.00004244271,0.0007052539,0.00001921509,0.0001063541,0.0002176737,0.8978238,0.0006830491],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000928082,0.9842156,0.00003361726,0.004738947,0.0002287814,0.002352827,0.007333594,0.00004402003,0.000124533],"genre_scores_gemma":[0.001175075,0.9944077,0.0004580127,0.00001294336,0.002237027,0.000774892,0.000672913,0.00008810536,0.0001733653],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.985563,"threshold_uncertainty_score":0.9998648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1610641221724899,"score_gpt":0.4852384805720364,"score_spread":0.3241743583995465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}