{"id":"W2560432428","doi":"10.21037/tlcr.2016.09.05","title":"Are immune checkpoint blockade monoclonal antibodies active against CNS metastases from NSCLC?—current evidence and future perspectives","year":2016,"lang":"en","type":"review","venue":"Translational Lung Cancer Research","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Blockade; Oncology; Immunotherapy; Monoclonal antibody; Immune checkpoint; Lung cancer; Disease; Immune system; Internal medicine; Clinical trial; Pembrolizumab; Atezolizumab; PD-L1; Targeted therapy; Antibody; Cancer; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009199366,0.0005215304,0.001703923,0.001302164,0.0001533785,0.001026376,0.0008396971,0.001105255,0.003650375],"category_scores_gemma":[0.0012198,0.0002308402,0.0008039338,0.001537244,0.0003791132,0.00139614,0.0004489233,0.001386017,0.001201875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003855002,"about_ca_system_score_gemma":0.0007916865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000639216,"about_ca_topic_score_gemma":0.001787405,"domain_scores_codex":[0.9997827,0.00004730562,0.00005481299,0.00003150897,0.00006640219,0.00001723802],"domain_scores_gemma":[0.9994454,0.00031342,0.0001000542,0.000009246191,0.0001060199,0.00002585092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0002121866,0.00006953757,0.0002030596,0.04182773,0.000226278,0.0001655107,0.00004666604,0.0001603698,0.000861172,0.001672992,0.01737811,0.9371764],"study_design_scores_gemma":[0.000131002,0.0003484692,0.001472922,0.0252505,0.0009902483,0.001607155,0.000126224,0.0001182704,0.0005475815,0.00229088,0.9670857,0.00003094749],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006574175,0.9994287,0.00001952067,0.0001782386,0.00006121473,0.000002456104,0.000009836612,0.0000016174,0.0002325049],"genre_scores_gemma":[0.0004439921,0.9991364,0.00005156215,0.0001701601,0.00007505139,0.000004396946,0.00001290035,4.961763e-7,0.0001050552],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003650375,"threshold_uncertainty_score":0.01221168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1610641221724899,"score_gpt":0.4852384805720364,"score_spread":0.3241743583995465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}