{"id":"W2560481339","doi":"10.1186/s13058-016-0786-1","title":"Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry","year":2016,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"National Cancer Institute; Seventh Framework Programme; National Medical Research Council; Canadian Institutes of Health Research; U.S. Department of Defense; Ministry of Public Health; Kementerian Sains, Teknologi dan Inovasi; Ministry of Higher Education, Malaysia; California Breast Cancer Research Program; Ministry of Education, Culture, Sports, Science and Technology; World Health Organization; Cancer Research UK; Division of Cancer Prevention, National Cancer Institute; Ministry of Education, Science and Technology; Génome Québec; European Commission; Breast Cancer Research Foundation; Woodcock Institute for the Advancement of Neurocognitive Research and Applied Practice; Ministry of Health, Labour and Welfare; Breast Cancer Research Trust; Biomedical Research Council; Francis Crick Institute; Vanderbilt University; California Department of Public Health; National University Cancer Institute, Singapore; National Institutes of Health; Ovarian Cancer Research Fund; McGill University","keywords":"Surgical oncology; Breast cancer; Medicine; Oncology; Internal medicine; Cancer; Demography; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001471995,0.0005812669,0.0003264735,0.0008480012,0.0002706842,0.0005085602,0.0002654575,0.0003218435,0.001204475],"category_scores_gemma":[0.003842652,0.0001922363,0.0005748678,0.000644525,0.0003524763,0.0002553711,0.0005106924,0.0004244476,0.0002850909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000208102,"about_ca_system_score_gemma":0.0001950029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005175108,"about_ca_topic_score_gemma":0.005222575,"domain_scores_codex":[0.9995885,0.0001566475,0.00003889891,0.00009881454,0.00006585895,0.0000512234],"domain_scores_gemma":[0.9983608,0.0005806877,0.0005859538,0.0001727281,0.0001560458,0.0001438067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001394287,0.000007921195,0.9967622,0.000006917362,0.0000896408,0.00006758142,0.00005800614,0.0001882535,0.0004958645,0.00001857768,0.00004659662,0.002119068],"study_design_scores_gemma":[0.000009210612,0.00006528528,0.997565,0.000007712315,0.0001330251,0.0002060197,0.00008483963,0.001414463,0.0002833225,0.0001121848,0.000114922,0.000004053985],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988382,0.0002021481,0.0004552645,0.00004236096,0.000004185312,0.000008026313,0.0001349179,0.00001092207,0.0003038272],"genre_scores_gemma":[0.9993599,0.00008418422,0.0003189344,0.00001239842,0.000004780959,0.000004830097,0.0001345677,0.000002568033,0.00007779118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005175108,"threshold_uncertainty_score":0.01028997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03687416484173791,"score_gpt":0.3425225226813257,"score_spread":0.3056483578395878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}