{"id":"W2560481339","doi":"10.1186/s13058-016-0786-1","title":"Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry","year":2016,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"National Cancer Institute; Seventh Framework Programme; National Medical Research Council; Canadian Institutes of Health Research; U.S. Department of Defense; Ministry of Public Health; Kementerian Sains, Teknologi dan Inovasi; Ministry of Higher Education, Malaysia; California Breast Cancer Research Program; Ministry of Education, Culture, Sports, Science and Technology; World Health Organization; Cancer Research UK; Division of Cancer Prevention, National Cancer Institute; Ministry of Education, Science and Technology; Génome Québec; European Commission; Breast Cancer Research Foundation; Woodcock Institute for the Advancement of Neurocognitive Research and Applied Practice; Ministry of Health, Labour and Welfare; Breast Cancer Research Trust; Biomedical Research Council; Francis Crick Institute; Vanderbilt University; California Department of Public Health; National University Cancer Institute, Singapore; National Institutes of Health; Ovarian Cancer Research Fund; McGill University","keywords":"Surgical oncology; Breast cancer; Medicine; Oncology; Internal medicine; Cancer; Demography; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006684076,0.000167321,0.0002424377,0.0002643826,0.00006833944,0.0000108639,0.0003877471,0.0001882689,0.0004449441],"category_scores_gemma":[0.00004432423,0.0001362949,0.00006074371,0.0005314471,0.0003688485,0.00001035393,0.0001110328,0.0002160072,0.000004904967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006307054,"about_ca_system_score_gemma":0.001307073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001870918,"about_ca_topic_score_gemma":0.0009080381,"domain_scores_codex":[0.9976457,0.0003529181,0.0003896815,0.0005063734,0.000587315,0.0005179652],"domain_scores_gemma":[0.9986058,0.00003605395,0.000176141,0.0006347084,0.0004177275,0.0001295627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002588941,0.0003431308,0.5259055,0.0001365949,0.0001004161,0.000004324447,0.0002383176,0.003022615,0.2807523,0.00001145026,0.001245128,0.1856512],"study_design_scores_gemma":[0.001902949,0.0002513382,0.9722682,0.0004211452,0.00001027382,0.00001454664,0.0001804501,0.0003909963,0.02379913,0.00008856559,0.0005329804,0.0001394196],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913471,0.0004136883,0.0001575623,0.001530315,0.0001802008,0.0003556979,0.005416886,0.000007780924,0.000590794],"genre_scores_gemma":[0.9981595,0.0006987508,0.0001036199,0.00004454162,0.0003012591,0.0005048827,0.00001540939,0.00003881368,0.0001331879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4463626,"threshold_uncertainty_score":0.5557943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03687416484173791,"score_gpt":0.3425225226813257,"score_spread":0.3056483578395878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}