{"id":"W2560489359","doi":"10.1002/iid3.136","title":"Transient Treg depletion enhances therapeutic anti‐cancer vaccination","year":2016,"lang":"en","type":"article","venue":"Immunity Inflammation and Disease","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Medical Research Council; National Health and Medical Research Council; Government of Western Australia; National Imaging Facility; Science and Industry Endowment Fund","keywords":"FOXP3; CD8; Immunity; Regulatory T cell; Vaccination; Immunology; Cancer research; Effector; Treg cell; Transgene; Immune system; Medicine; T cell; Biology; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001413202,0.0003610525,0.0004066312,0.0002323999,0.00009407276,0.0002345499,0.0002087807,0.0003356378,0.0024768],"category_scores_gemma":[0.0001088038,0.0001064803,0.0001930088,0.0001084378,0.0001838251,0.0002165009,0.0001877204,0.0009435778,0.0004624105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001338321,"about_ca_system_score_gemma":0.0001647931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001627189,"about_ca_topic_score_gemma":0.0003460376,"domain_scores_codex":[0.9998435,0.0000213567,0.00001120102,0.00003516716,0.00003836073,0.00005034653],"domain_scores_gemma":[0.9999071,0.00002329397,0.00002323859,0.00001357461,0.000007878682,0.00002484294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002686531,0.0002652878,0.0001653676,0.00008197568,0.000007604309,0.00003566736,0.000008620066,0.0001876863,0.9928496,0.00008728189,0.0001534364,0.005888862],"study_design_scores_gemma":[0.0000889256,0.004231187,0.002787236,0.00002195698,0.00005268643,0.000429503,0.000009685745,0.001308705,0.9866242,0.00006676093,0.004372775,0.000006346193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848415,0.004882349,0.006041327,0.0001405923,0.0001575877,0.0001209602,0.0003684548,0.0004382126,0.003009029],"genre_scores_gemma":[0.9928117,0.00146323,0.002594428,0.0001187447,0.00006374168,0.00007677415,0.0004602739,0.00003805282,0.002372999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0024768,"threshold_uncertainty_score":0.008285761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297621478365046,"score_gpt":0.2536801851314822,"score_spread":0.2407039703478317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}