{"id":"W2560508979","doi":"10.1161/strokeaha.116.014250","title":"Randomized, Open-Label, Phase 1/2a Study to Determine the Maximum Tolerated Dose of Intraventricular Sustained Release Nimodipine for Subarachnoid Hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage])","year":2016,"lang":"en","type":"article","venue":"Stroke","topic":"Intracranial Aneurysms: Treatment and Complications","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Medicine; Nimodipine; Anesthesia; Tolerability; Subarachnoid hemorrhage; Randomized controlled trial; Confidence interval; Adverse effect; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001997889,0.00166828,0.002342783,0.000401593,0.0004547535,0.0008692261,0.0009076456,0.001490814,0.004757809],"category_scores_gemma":[0.001594163,0.0008366925,0.0008123299,0.0003597841,0.00126739,0.0008604299,0.0003044751,0.002333087,0.0008303995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006969832,"about_ca_system_score_gemma":0.00151873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000547699,"about_ca_topic_score_gemma":0.001434649,"domain_scores_codex":[0.9991891,0.0004534847,0.00004154603,0.0001353301,0.00007798956,0.0001025514],"domain_scores_gemma":[0.9987304,0.0003169541,0.0003548382,0.0001276316,0.00008939557,0.0003808248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9394668,0.0367578,0.001238035,0.0001979122,0.0004775446,0.00006239388,0.00006005726,0.0003189939,0.01133928,0.00009704853,0.0006992774,0.009284852],"study_design_scores_gemma":[0.8685143,0.1278607,0.001591329,0.000008719944,0.0001598344,0.00003743553,0.00001207452,0.000391158,0.0009290919,0.00007738424,0.0004079919,0.000009989898],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910228,0.0007729527,0.0009611446,0.0002850898,0.000230501,0.005037784,0.0007515491,0.0000973203,0.0008409453],"genre_scores_gemma":[0.9845596,0.0008353429,0.003353683,0.001111203,0.0003754236,0.006648337,0.0009245098,0.00003281935,0.002159139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004757809,"threshold_uncertainty_score":0.01591653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02046556579093275,"score_gpt":0.2982935284058083,"score_spread":0.2778279626148755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}