{"id":"W2560508979","doi":"10.1161/strokeaha.116.014250","title":"Randomized, Open-Label, Phase 1/2a Study to Determine the Maximum Tolerated Dose of Intraventricular Sustained Release Nimodipine for Subarachnoid Hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage])","year":2016,"lang":"en","type":"article","venue":"Stroke","topic":"Intracranial Aneurysms: Treatment and Complications","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Medicine; Nimodipine; Anesthesia; Tolerability; Subarachnoid hemorrhage; Randomized controlled trial; Confidence interval; Adverse effect; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009568754,0.0005399275,0.001230689,0.0002700953,0.0003109858,0.0001155546,0.0005966767,0.0001047094,0.0002674246],"category_scores_gemma":[0.0008516795,0.0003320856,0.0002417869,0.0006900976,0.0001568747,0.0002675779,0.0003095832,0.000196012,0.00006687758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002428713,"about_ca_system_score_gemma":0.0001743575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002298403,"about_ca_topic_score_gemma":0.00009710313,"domain_scores_codex":[0.9964249,0.0002712605,0.001158326,0.000940754,0.000418203,0.0007866113],"domain_scores_gemma":[0.9969451,0.0003771504,0.0003216822,0.00127229,0.0006757882,0.0004079824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2005292,0.007005941,0.0002146491,0.0002084745,0.0001485127,0.0003833995,0.0005642964,0.00002006762,0.7369008,0.00004740182,0.000260367,0.05371683],"study_design_scores_gemma":[0.1927315,0.008372611,0.0003996623,0.0001172675,0.001437399,0.000164508,0.0006545954,0.002555909,0.7925934,0.0002007717,0.0001297695,0.0006425476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688001,0.0002525631,0.01025424,0.009267662,0.0001700937,0.01061764,0.0004268606,0.0001053592,0.0001054456],"genre_scores_gemma":[0.9864452,0.000007371948,0.006013523,0.0008003013,0.0002752187,0.002573442,0.00006693297,0.00007560919,0.003742356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05569259,"threshold_uncertainty_score":0.9999131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02046556579093275,"score_gpt":0.2982935284058083,"score_spread":0.2778279626148755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}