{"id":"W2560511456","doi":"10.1016/j.cell.2016.11.017","title":"Naturally Occurring Off-Switches for CRISPR-Cas9","year":2016,"lang":"en","type":"letter","venue":"Cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":414,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; CRISPR; Cas9; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007913505,0.0003089249,0.000222035,0.00004984092,0.00005128219,0.00003053932,0.0003306804,0.000771163,0.00003043318],"category_scores_gemma":[0.00003390608,0.0002611908,0.0002345289,0.00002543551,0.00003111035,0.000001518685,0.0001092845,0.0003261977,0.00003337428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001590628,"about_ca_system_score_gemma":0.00006980581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002209661,"about_ca_topic_score_gemma":0.000002857208,"domain_scores_codex":[0.9987242,0.00001110541,0.0002021967,0.0004963648,0.0001124728,0.0004536878],"domain_scores_gemma":[0.9992882,0.00002863137,0.00007665554,0.0004773336,0.00007834054,0.00005082663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00000870769,0.000003555582,0.00001177256,0.0001942893,0.00003055715,0.000006834743,0.000009297504,0.000006913322,0.2429385,7.055426e-7,0.755066,0.001722821],"study_design_scores_gemma":[0.0002497218,0.00005877426,0.000006877313,0.00003123537,0.00002765849,0.000006083538,0.000003942454,0.000009306223,0.3159494,0.00002259072,0.6833546,0.000279888],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.04868797,0.1093835,0.2682715,0.5059521,0.01927179,0.005750525,0.002515392,0.000532501,0.0396347],"genre_scores_gemma":[0.06082582,0.001814747,0.008110882,0.7686265,0.05936426,0.000448987,0.003173765,0.0006862314,0.09694885],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2626743,"threshold_uncertainty_score":0.999984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008251045516481486,"score_gpt":0.2743337778846146,"score_spread":0.2660827323681331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}