{"id":"W2560517946","doi":"10.1016/j.bpj.2016.10.016","title":"Membrane-Bound Alpha Synuclein Clusters Induce Impaired Lipid Diffusion and Increased Lipid Packing","year":2016,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Vrije Universiteit Amsterdam; Universität Konstanz; University of Alberta","keywords":"Fluorescence recovery after photobleaching; Chemistry; Membrane; Biophysics; Phospholipid; Protein–lipid interaction; Lipid bilayer; Membrane fluidity; Biological membrane; Protein aggregation; Membrane biophysics; Membrane protein; Monomer; Lipid microdomain; Fluorescence anisotropy; Fibril; Biochemistry; Integral membrane protein; Biology; Polymer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001594348,0.0005178282,0.0005190354,0.0002180875,0.0003687874,0.0003891324,0.0002671706,0.0006546171,0.001245436],"category_scores_gemma":[0.0002234485,0.0003623259,0.0003585067,0.0001635982,0.0003938426,0.0003083904,0.0005386285,0.0009795807,0.0006082707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005826334,"about_ca_system_score_gemma":0.0002960488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001094448,"about_ca_topic_score_gemma":0.001036597,"domain_scores_codex":[0.9997321,0.00004558148,0.00002474349,0.00005765503,0.00008370776,0.00005618421],"domain_scores_gemma":[0.9996907,0.000059543,0.00008024446,0.00004472077,0.00003440443,0.00009049435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002720176,0.00002250923,0.00005703957,0.00001152873,0.000008141757,0.00006101638,0.0000130245,0.00005147153,0.9992579,0.00006287147,0.00003178141,0.0001506914],"study_design_scores_gemma":[0.00002090769,0.0001204883,0.001258642,0.000002814726,0.00001188354,0.0001909366,0.00002290504,0.0007819457,0.9971725,0.0000713333,0.0003408507,0.000004798859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996362,0.0003109798,0.002250341,0.0001171757,0.00004780268,0.00002199304,0.00021623,0.00005682662,0.0006167291],"genre_scores_gemma":[0.9968626,0.0001500944,0.001049562,0.00005194352,0.000009457136,0.00002157882,0.0003000453,0.00004936409,0.001505334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001245436,"threshold_uncertainty_score":0.00422734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009656546907786516,"score_gpt":0.2381610452326837,"score_spread":0.2285044983248971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}