{"id":"W2560528745","doi":"10.1128/jvi.01402-16","title":"Toll-Like Receptor 2 Ligation Enhances HIV-1 Replication in Activated CCR6 <sup>+</sup> CD4 <sup>+</sup> T Cells by Increasing Virus Entry and Establishing a More Permissive Environment to Infection","year":2016,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Biology; Permissive; Viral replication; Virology; Viral entry; Toll-like receptor; Replication (statistics); Virus; Cell biology; Permissiveness; Receptor; C-C chemokine receptor type 6; Ligation; Human immunodeficiency virus (HIV); Chemokine receptor; Innate immune system; Molecular biology; Genetics; Chemokine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001401379,0.0002683869,0.0002503335,0.0001212821,0.0001069875,0.0004100667,0.0001296449,0.0001772624,0.002243329],"category_scores_gemma":[0.0001079282,0.0001108686,0.0001946471,0.00007274166,0.0001016564,0.0001305698,0.0001726267,0.0004429135,0.0005299177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009317321,"about_ca_system_score_gemma":0.0000990485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001820523,"about_ca_topic_score_gemma":0.0002610367,"domain_scores_codex":[0.9998135,0.0000565213,0.00001989357,0.00002244738,0.00003273031,0.00005489193],"domain_scores_gemma":[0.9999013,0.00002156243,0.00001634827,0.00001426299,0.0000109767,0.0000355868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001326016,0.00002190911,0.0001378048,0.00001946218,0.000001711936,0.0000269665,0.00000829598,0.00002502633,0.9992803,0.00001337662,0.00001322314,0.0003195279],"study_design_scores_gemma":[0.0000508307,0.001010661,0.005988041,0.000006682043,0.00001812568,0.0003278184,0.00005101461,0.001010232,0.9901578,0.00002749476,0.001346591,0.000004676127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985455,0.0003469584,0.0005128173,0.00003054396,0.00001482727,0.00001341134,0.00009730727,0.00001797166,0.0004205166],"genre_scores_gemma":[0.9962044,0.0002561852,0.001610618,0.00004894358,0.00002734954,0.000030892,0.0003155934,0.00001433344,0.001491646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002243329,"threshold_uncertainty_score":0.007504702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007671221247811898,"score_gpt":0.2457208650212109,"score_spread":0.238049643773399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}