{"id":"W2560538705","doi":"10.1016/j.gde.2016.10.006","title":"Chromosome folding and its regulation in health and disease","year":2016,"lang":"en","type":"review","venue":"Current Opinion in Genetics & Development","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canadian Cancer Society; Cole Foundation; Canadian Cardiovascular Society","keywords":"CTCF; Biology; Chromatin; Hox gene; Gene; Regulation of gene expression; Chromosome conformation capture; Computational biology; Genetics; ChIA-PET; Gene expression; Genomic organization; Genome; Chromatin remodeling; Evolutionary biology; Enhancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004098894,0.0003500509,0.0005239819,0.0003365304,0.0000630412,0.00003490823,0.0001690083,0.0002196054,0.000009066728],"category_scores_gemma":[0.0001050643,0.0003256375,0.00005902387,0.0002001656,0.00003551373,0.000003933087,0.0004267157,0.0002226807,0.000006714735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000260527,"about_ca_system_score_gemma":0.001902223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.786775e-7,"about_ca_topic_score_gemma":0.000003725313,"domain_scores_codex":[0.9976153,0.0002077901,0.0007187112,0.0007625404,0.0002659119,0.0004297075],"domain_scores_gemma":[0.9990555,0.00001803934,0.0002168687,0.000264457,0.00004776935,0.0003973666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001428019,0.00004142573,0.00001854405,0.01138199,0.00002514204,9.105859e-7,0.00005440945,0.000006072591,0.0001069814,0.0001253981,0.0002036497,0.9880212],"study_design_scores_gemma":[0.0004891927,0.00005869789,0.0001016153,0.02025542,0.000006771673,0.000007539561,0.000003868413,0.00004004618,0.0001248774,0.00008392715,0.9784518,0.0003762151],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000137888,0.9966464,0.001177686,0.00006108081,0.0008084755,0.001129162,0.00002699193,0.000006132078,0.000006191707],"genre_scores_gemma":[0.0002257859,0.9983697,0.0003251777,0.00001174631,0.0001859269,0.0002650419,0.0005213911,0.0000521072,0.00004312574],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.987645,"threshold_uncertainty_score":0.9999196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06954318700340466,"score_gpt":0.3948885125611061,"score_spread":0.3253453255577014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}