{"id":"W2560538705","doi":"10.1016/j.gde.2016.10.006","title":"Chromosome folding and its regulation in health and disease","year":2016,"lang":"en","type":"review","venue":"Current Opinion in Genetics & Development","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canadian Cancer Society; Cole Foundation; Canadian Cardiovascular Society","keywords":"CTCF; Biology; Chromatin; Hox gene; Gene; Regulation of gene expression; Chromosome conformation capture; Computational biology; Genetics; ChIA-PET; Gene expression; Genomic organization; Genome; Chromatin remodeling; Evolutionary biology; Enhancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000787119,0.0008847248,0.001591007,0.0012551,0.0003082801,0.001352631,0.0009967681,0.001625545,0.003110083],"category_scores_gemma":[0.0005425081,0.0003095923,0.0003674779,0.002110491,0.001003838,0.001589563,0.001269385,0.001658105,0.001935849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009054465,"about_ca_system_score_gemma":0.001202611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007317753,"about_ca_topic_score_gemma":0.001401367,"domain_scores_codex":[0.9998087,0.00003294127,0.00002378384,0.00004153038,0.00006326802,0.00002974617],"domain_scores_gemma":[0.9998236,0.00006609236,0.00003316462,0.000008369527,0.00004420042,0.00002462316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001406551,0.00003866582,0.0002657697,0.009140603,0.00008227408,0.0002331456,0.0000724801,0.0005268038,0.005245369,0.01092409,0.0343161,0.939014],"study_design_scores_gemma":[0.00001882447,0.00004613151,0.000754283,0.001628088,0.00008057049,0.0005567062,0.00008948157,0.0001411878,0.0009393683,0.006282669,0.989442,0.00002060097],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001336688,0.9978068,0.0002864745,0.000604501,0.0003755805,0.000002660721,0.00001885467,0.000008808052,0.0007626337],"genre_scores_gemma":[0.001025546,0.9976519,0.0001933001,0.0002159079,0.0003109417,0.00000533073,0.0000354226,0.000001695185,0.0005599365],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003110083,"threshold_uncertainty_score":0.01040423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06954318700340466,"score_gpt":0.3948885125611061,"score_spread":0.3253453255577014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}